Results 131 to 140 of about 117,696 (250)

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source

Antitrypanosomal properties of Anogeissus leiocarpa extracts and their inhibitory effect on trypanosome alternative oxidase. [PDF]

Phytomed Plus, 2022
Tauheed AM, Mamman M, Ahmed A, Suleiman MM, Balogun EO.   +4 more
europepmc   +1 more source

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism? [PDF]

Biochem J, 2022
Szibor M, Schenkl C, Barsottini MRO, Young L, Moore AL.   +4 more
europepmc   +1 more source

Sequencing of a Soybean Alternative Oxidase cDNA Clone [PDF]

Plant Physiology, 1993
J, Whelan, L, McIntosh, D A, Day
openaire   +2 more sources

Spatially Encoded Protocell Network for Non‐Cascaded Parallel Biocomputation

Advanced Science, EarlyView.
A non‐cascaded, hydrogel‐based proteinosome computational platform is developed, in which redox‐responsive proteinosomes serve as local computing units within a shared reaction–diffusion field. Reductant inputs, countered by an auxiliary glucose gradient, regulate spatially patterned proteinosome disruption, and generate population‐level boundaries ...
Shuqi Wu, Liangfei Tian
wiley   +1 more source

Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure-Activity Relationship Studies. [PDF]

ACS Med Chem Lett, 2022
Cisneros D, Cueto-Díaz EJ, Medina-Gil T, Chevillard R, Bernal-Fraile T, López-Sastre R, Aldfer MM, Ungogo MA, Elati HAA, Arai N, Otani M, Matsushiro S, Kojima C, Ebiloma GU, Shiba T, de Koning HP, Dardonville C.   +16 more
europepmc   +1 more source

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

Different Metabolic Roles for Alternative Oxidase in Leaves of Palustrine and Terrestrial Species. [PDF]

Front Plant Sci, 2021
Del-Saz NF, Douthe C, Carriquí M, Ortíz J, Sanhueza C, Rivas-Medina A, McDonald A, Fernie AR, Ribas-Carbo M, Gago J, Florez-Sarasa I, Flexas J.   +11 more
europepmc   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source