Results 161 to 170 of about 3,088,451 (275)

Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism? [PDF]

Biochem J, 2022
Szibor M, Schenkl C, Barsottini MRO, Young L, Moore AL.   +4 more
europepmc   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Ligand-induced reshaping of the conformational free energy landscape drives dynamic restriction in Trypanosoma brucei alternative oxidase. [PDF]

J Comput Aided Mol Des
Mas'od NH, Bahari MNA, Ayub WMW, Jamali MAM.   +3 more
europepmc   +1 more source

Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure-Activity Relationship Studies. [PDF]

ACS Med Chem Lett, 2022
Cisneros D, Cueto-Díaz EJ, Medina-Gil T, Chevillard R, Bernal-Fraile T, López-Sastre R, Aldfer MM, Ungogo MA, Elati HAA, Arai N, Otani M, Matsushiro S, Kojima C, Ebiloma GU, Shiba T, de Koning HP, Dardonville C.   +16 more
europepmc   +1 more source

Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions

Advanced Science, EarlyView.
This study uncovers a tri‐directional interplay among cells, hydrogels, and their nascent extracellular matrix. Hydrogel norbornene modification alters CD44‐mediated cell–hydrogel interactions, which shape nascent matrix deposition, composition, and spatial organization.
Joshua Y. Liu, Ziqian Yang, Arina E. Velieva, Eleanor M. Plaster, Mingyue Fan, Donia W. Ahmed, Avinava Roy, Pamela Duran, Pamela Panovich, Alexandra S. Piotrowski‐Daspit, Carlos A. Aguilar, Megan L. Killian, Claudia Loebel   +12 more
wiley   +1 more source

Impaired Photorespiratory Metabolism Underlies the Decline in CO₂ Assimilation Induced by Alternative Oxidase Inhibition in <i>Rumex</i> K-1 Leaves. [PDF]

Plants (Basel)
Zhong X, Li S, Zhang L.
europepmc   +1 more source

Different Metabolic Roles for Alternative Oxidase in Leaves of Palustrine and Terrestrial Species. [PDF]

Front Plant Sci, 2021
Del-Saz NF, Douthe C, Carriquí M, Ortíz J, Sanhueza C, Rivas-Medina A, McDonald A, Fernie AR, Ribas-Carbo M, Gago J, Florez-Sarasa I, Flexas J.   +11 more
europepmc   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Alternative oxidase and ethylene form a positive feed-forward loop in mitochondrial retrograde signaling. [PDF]

Plant Commun
He C, Narsai R, Liew LC, Zhang Y, Yin L, Xu J, Xie M, Shou H, Ecker JR, Lewsey MG, Wang Y, Berkowitz O, Whelan J.   +12 more
europepmc   +1 more source

Bioelectrochemically Powered Out‐of‐Equilibrium Hydrogels Enable Feedback‐Regulated Functions

Advanced Science, EarlyView.
A bioelectrochemically powered hydrogel operates far from equilibrium via an antagonistic redox cycle that regulates disulfide exchange within a polyrotaxane network. Coupling electrochemical mediator cycling with enzymatic feedback enables dynamic control of hydrogel mechanics and transport properties, driving glucose‐responsive insulin release with ...
Roberto Baretta, Marco Frasconi
wiley   +1 more source