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Exploring vimentin's role in breast cancer via PICK1 alternative polyadenylation and the miR-615-3p-PICK1 interaction. [PDF]
BiofactorsJia X, Shao L, Quan H, Zhong Z, Dong C.
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Advances in Alternative Polyadenylation in Tumors
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Alternative polyadenylation regulation: insights from sequential polyadenylation
Transcription, 2022The processing of the proximal and distal poly(A) sites in alternative polyadenylation (APA) has long been thought to independently occur on pre-mRNAs during transcription. However, a recent study by our groups demonstrated that the proximal sites for many genes could be activated sequentially following the distal ones, suggesting a multi-cleavage-same-
Peng Tang, Yu Zhou
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Alternative polyadenylation and the stress response
WIREs RNA, 2019AbstractThe cellular stress response is a universal mechanism necessary for the survival of all organisms. This multifaceted process is primarily driven by regulation of gene expression to produce an intracellular environment suitable for promoting cell survival and recovery.
Jason Sadek +4 more
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Detecting Alternative Polyadenylation from Microarray Data
2014Gene regulation at the posttranscriptional level is often mediated by trans-acting factors binding the 3' untranslated region (3' UTR) of messenger RNAs (mRNAs). Alternative mRNA isoforms differing only in their 3' UTR can thus be differentially regulated, and it has been recently shown that this mechanism is indeed used by the cell to alter gene ...
Antonio, Lembo, Paolo, Provero
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Unleashing alternative polyadenylation analyses with REPAC
2022AbstractAlternative polyadenylation (APA) is an important post-transcriptional mechanism that has major implications in biological processes and diseases. Although specialized sequencing methods for polyadenylation exist, their presence in public repositories is extremely limited when compared to traditional RNA-sequencing.
Eddie L Imada +3 more
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Quantifying alternative polyadenylation in RNAseq data with LABRAT
2021Alternative polyadenylation (APA) generates transcript isoforms that differ in their 3' UTR content and may therefore be subject to different regulatory fates. Although the existence of APA has been known for decades, quantification of APA isoforms from high-throughput RNA sequencing data has been difficult.
Austin E, Gillen +2 more
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Alternative Polyadenylation and Its Impact on Cellular Processes
MicroRNA, 2014Impact of mRNA processing and/or modifications has long been associated with gene expression regulation. Accumulating evidence shows alternative polyadenylation (APA), as an mRNA related process, to emerge as a widespread mechanism in gene expression regulation.
Hesna B, Akman, Ayse E, Erson-Bensan
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