Poly(A) tail dynamics, non-adenine incorporation and alternative polyadenylation shape the host transcriptome in COVID-19 pathogenesis. [PDF]
Maździarz MA +11 more
europepmc +1 more source
Multitissue single-nucleus RNA-seq reveals cell type-specific regulatory patterns of alternative polyadenylation in pigs. [PDF]
Wen Q +8 more
europepmc +1 more source
Vimentin Regulates Alternative Polyadenylation and mTOR Signaling via ARVCF to Promote B Cell Lymphoma Progression. [PDF]
Shao L +6 more
europepmc +1 more source
The Dynamic Landscape of 3'-UTR Alternative Polyadenylation Across Mouse Fetal Development and Anatomy. [PDF]
Wang Q, Chen X, Zhang XO.
europepmc +1 more source
Advances in Alternative Polyadenylation in Tumors
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Coupling between alternative polyadenylation and alternative splicing is limited to terminal introns [PDF]
Alternative polyadenylation has been implicated as an important regulator of gene expression. In some cases, alternative polyadenylation is known to couple with alternative splicing to influence last intron removal.
Maliheh Movassat +2 more
exaly +2 more sources
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Alternative polyadenylation regulation: insights from sequential polyadenylation
Transcription, 2022The processing of the proximal and distal poly(A) sites in alternative polyadenylation (APA) has long been thought to independently occur on pre-mRNAs during transcription. However, a recent study by our groups demonstrated that the proximal sites for many genes could be activated sequentially following the distal ones, suggesting a multi-cleavage-same-
Peng Tang, Yu Zhou
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Alternative polyadenylation and the stress response
WIREs RNA, 2019AbstractThe cellular stress response is a universal mechanism necessary for the survival of all organisms. This multifaceted process is primarily driven by regulation of gene expression to produce an intracellular environment suitable for promoting cell survival and recovery.
Jason Sadek +4 more
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The soluble neuropilin-1 (sNRP-1) gene employs an extremely short dual function polyadenylation (pA) signal/stop codon that is efficient for termination of gene transcription and translation in vivo. However, the functionality and usefulness of this signal in regard to other genes is unknown.
Trevor J, McFarland +5 more
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