Results 201 to 210 of about 30,645 (223)

Quantifying alternative polyadenylation in RNAseq data with LABRAT

2021
Alternative polyadenylation (APA) generates transcript isoforms that differ in their 3' UTR content and may therefore be subject to different regulatory fates. Although the existence of APA has been known for decades, quantification of APA isoforms from high-throughput RNA sequencing data has been difficult.
Austin E, Gillen, Raeann, Goering, J Matthew, Taliaferro   +2 more
openaire   +2 more sources

Dynamics of alternative polyadenylation in human preimplantation embryos

Biochemical and Biophysical Research Communications, 2018
Alternative polyadenylation (APA) affects the length of the 3' untranslated region (3'-UTR) and the regulation of microRNAs. Previous studies have shown that cancer cells tend to have shorter 3'-UTRs than normal cells. A plausible explanation for this is that it enables cancer cells to escape the regulation of microRNAs. Here, we extend this concept to
Jen-Yun Chang, Wen-Hsuan Yu, Hsueh-Fen Juan, Hsuan-Cheng Huang   +3 more
openaire   +2 more sources

A special focus on polyadenylation and alternative polyadenylation in neurodegenerative diseases: A systematic review

Journal of Neurochemistry
Abstract Neurodegenerative diseases (NDDs) are one of the prevailing conditions characterized by progressive neuronal loss. Polyadenylation (PA) and alternative polyadenylation (APA) are the two main post‐transcriptional events that regulate neuronal gene expression and protein production.
Tarlan, Yeganeh Markid, Azam, Pourahmadiyan, Soroosh, Hamzeh, Mirmohsen, Sharifi-Bonab, Mohamad Reza, Asadi, Abbas, Jalaiei, Maryam, Rezazadeh, Soudeh, Ghafouri-Fard   +7 more
openaire   +2 more sources

Alternative polyadenylation and gene expression regulation in plants

WIREs RNA, 2010
AbstractFunctioning as an essential step of pre‐mRNA processing, polyadenylation has been realized in recent years to play an important regulatory role during eukaryotic gene expression. Such regulation occurs mostly through the use of alternative polyadenylation (APA) sites and generates different transcripts with altered coding capacity for proteins ...
Denghui, Xing, Qingshun Quinn, Li
openaire   +2 more sources

Alternative polyadenylation at Mest

Imprinting, an epigenetic phenomenon where only one allele of a gene is expressed depending on its parental origin, plays a significant role in mammalian development. The sub-proximal MMU6 imprinting domain, particularly, includes the paternally expressed gene Mest and the maternally expressed genes Copg2 and Klf14. In addition to the mature mRNA, Mest
openaire   +1 more source

DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex

Molecular Cell, 2020
Vishal Nanavaty, Byron H Lee, Tae Hyun Hwang   +2 more
exaly  

RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts

Cell Reports, 2021
Jun Cao, Elizabeth Jaworski, Stephanie D Mohan   +2 more
exaly  

Alternative Splicing and Alternative Polyadenylation in Moso Bamboo

2021
Lianfeng Gu, Hangxiao Zhang, Jian Gao
openaire   +1 more source

Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism

Cell Stem Cell, 2020
Pia Sommerkamp, Sandro Altamura, Simon Renders   +2 more
exaly  

A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex

Molecular Cell, 2020
Seung Wook Yang, Lei Li, Jon P Connelly
exaly