Results 231 to 240 of about 3,647,679 (259)

Alternative polyadenylation regulation in cardiac development and cardiovascular disease.

Cardiovascular Research, 2023
Cleavage and polyadenylation of pre-mRNAs is a necessary step for gene expression and function. Majority of human genes exhibit multiple polyadenylation sites, which can be alternatively used to generate different mRNA isoforms from a single gene ...
Jun Cao, Muge N. Kuyumcu-Martinez
semanticscholar   +1 more source

Landscape and regulation of alternative splicing and alternative polyadenylation in a plant pathogenic fungus.

New Phytologist, 2022
Alternative splicing (AS) and alternative polyadenylation (APA) contribute significantly to the regulation of gene expression in higher eukaryotes. Their biological impact in filamentous fungi, however, is largely unknown.
Ping Lu, Daipeng Chen, Zhaomei Qi, Haoming Wang, Yitong Chen, Qinhu Wang, Cong Jiang, Jin-Rong Xu, Huiquan Liu   +8 more
semanticscholar   +1 more source

Alternative polyadenylation and the stress response

WIREs RNA, 2019
AbstractThe cellular stress response is a universal mechanism necessary for the survival of all organisms. This multifaceted process is primarily driven by regulation of gene expression to produce an intracellular environment suitable for promoting cell survival and recovery.
Jason Sadek, Amr Omer, Derek Hall, Kholoud Ashour, Imed Eddine Gallouzi   +4 more
openaire   +2 more sources

Dynamic regulation of alternative polyadenylation by PQBP1 during neurogenesis.

Cell Reports
Alternative polyadenylation (APA) is a critical post-transcriptional process that generates mRNA isoforms with distinct 3' untranslated regions (3' UTRs), thereby regulating mRNA localization, stability, and translational efficiency.
Xian Liu, Hao Xie, Wenhua Liu, Jian Zuo, Song Li, Yao Tian, Jingrong Zhao, Meizhu Bai, Jinsong Li, Lan Bao, Junhai Han, Zi Chao Zhang   +11 more
semanticscholar   +1 more source

Alternative polyadenylation: An enigma of transcript length variation in health and disease

Wiley Interdisciplinary Reviews - RNA, 2021
Alternative polyadenylation (APA) is a molecular mechanism during a pre‐mRNA processing that involves usage of more than one polyadenylation site (PA‐site) generating transcripts of varying length from a single gene.
Neeraja K Mohanan, Feba Shaji, Ganesh R Koshre, Rakesh S. Laishram   +3 more
semanticscholar   +1 more source

Detecting Alternative Polyadenylation from Microarray Data

2014
Gene regulation at the posttranscriptional level is often mediated by trans-acting factors binding the 3' untranslated region (3' UTR) of messenger RNAs (mRNAs). Alternative mRNA isoforms differing only in their 3' UTR can thus be differentially regulated, and it has been recently shown that this mechanism is indeed used by the cell to alter gene ...
Antonio, Lembo, Paolo, Provero
openaire   +2 more sources

Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation.

Trends in Molecular Medicine, 2021
Cellular function is shaped by transcriptional and post-transcriptional mechanisms, including alternative polyadenylation (APA). By directly controlling 3'- untranslated region (UTR) length and the selection of the last exon, APA regulates up to 70% of ...
Pia Sommerkamp, Nina Cabezas-Wallscheid, A. Trumpp   +2 more
semanticscholar   +1 more source

Unleashing alternative polyadenylation analyses with REPAC

2022
AbstractAlternative polyadenylation (APA) is an important post-transcriptional mechanism that has major implications in biological processes and diseases. Although specialized sequencing methods for polyadenylation exist, their presence in public repositories is extremely limited when compared to traditional RNA-sequencing.
Eddie L Imada, Christopher Wilks, Ben Langmead, Luigi Marchionni   +3 more
openaire   +1 more source

Quantifying alternative polyadenylation in RNAseq data with LABRAT

2021
Alternative polyadenylation (APA) generates transcript isoforms that differ in their 3' UTR content and may therefore be subject to different regulatory fates. Although the existence of APA has been known for decades, quantification of APA isoforms from high-throughput RNA sequencing data has been difficult.
Austin E, Gillen, Raeann, Goering, J Matthew, Taliaferro   +2 more
openaire   +2 more sources

Alternative Polyadenylation and Its Impact on Cellular Processes

MicroRNA, 2014
Impact of mRNA processing and/or modifications has long been associated with gene expression regulation. Accumulating evidence shows alternative polyadenylation (APA), as an mRNA related process, to emerge as a widespread mechanism in gene expression regulation.
Hesna B, Akman, Ayse E, Erson-Bensan
openaire   +2 more sources