Results 91 to 100 of about 3,325,944 (356)

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

open access: yesPLoS Genetics, 2018
The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3’ UTRs.
Seth D. Kasowitz   +8 more
semanticscholar   +1 more source

Landscape of BRAF transcript variants in human cancer

open access: yesMolecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda   +5 more
wiley   +1 more source

Editorial on alternative splicing and disease [PDF]

open access: yesRNA Biology, 2010
(2010). Editorial on alternative splicing and disease. RNA Biology: Vol. 7, No. 4, pp. 388-389.
Barta Andrea, Schuemperli Daniel
openaire   +4 more sources

CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing

open access: yesRNA Biology
The Cell Division Cycle and Apoptosis Regulator (CCAR) protein family members have recently emerged as regulators of alternative splicing and transcription, as well as having other key physiological functions.
Doreen I. Lugano   +4 more
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

A New Twist to Ibuprofen: Alternative Action in Alternative Splicing

open access: yesEuropean Medical Journal, 2019
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and is a widely used medication. One indication of NSAID use is long-term chemoprevention to decrease the risk of developing various types of cancer, in particular colorectal cancer.
Peter Jordan   +2 more
doaj  

Aberrant alternative splicing in breast cancer

open access: yesJournal of Molecular Cell Biology, 2019
Alternative splicing is critical for human gene expression regulation, which plays a determined role in expanding the diversity of functional proteins.
Quan Yang   +4 more
semanticscholar   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

open access: yesMolecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo   +11 more
wiley   +1 more source

Regrowing axons with alternative splicing [PDF]

open access: yeseLife, 2016
The regeneration of axons relies on a previously unknown mechanism that involves the regulation of alternative splicing by CELF proteins.
Nicholas J Kramer, Aaron D Gitler
openaire   +3 more sources

RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing

open access: yesbioRxiv, 2018
Alternative splicing of pre-mRNAs plays a pivotal role during the establishment and maintenance of human cell types. Characterizing the trans-acting regulatory proteins that control alternative splicing in both healthy and malignant cells has therefore ...
H. Dvinge   +3 more
semanticscholar   +1 more source

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