Results 91 to 100 of about 3,325,944 (356)
PLoS Genetics, 2018 The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3’ UTRs.
Seth D. Kasowitz +8 more
semanticscholar +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Editorial on alternative splicing and disease [PDF]
RNA Biology, 2010 (2010). Editorial on alternative splicing and disease. RNA Biology: Vol. 7, No. 4, pp. 388-389.
Barta Andrea, Schuemperli Daniel
openaire +4 more sources
CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing
RNA BiologyThe Cell Division Cycle and Apoptosis Regulator (CCAR) protein family members have recently emerged as regulators of alternative splicing and transcription, as well as having other key physiological functions.
Doreen I. Lugano +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
A New Twist to Ibuprofen: Alternative Action in Alternative Splicing
European Medical Journal, 2019 Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and is a widely used medication. One indication of NSAID use is long-term chemoprevention to decrease the risk of developing various types of cancer, in particular colorectal cancer.
Peter Jordan +2 more
doaj
Aberrant alternative splicing in breast cancer
Journal of Molecular Cell Biology, 2019 Alternative splicing is critical for human gene expression regulation, which plays a determined role in expanding the diversity of functional proteins.
Quan Yang +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo +11 more
wiley +1 more source
Regrowing axons with alternative splicing [PDF]
eLife, 2016 The regeneration of axons relies on a previously unknown mechanism that involves the regulation of alternative splicing by CELF proteins.
Nicholas J Kramer, Aaron D Gitler
openaire +3 more sources
RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing
bioRxiv, 2018 Alternative splicing of pre-mRNAs plays a pivotal role during the establishment and maintenance of human cell types. Characterizing the trans-acting regulatory proteins that control alternative splicing in both healthy and malignant cells has therefore ...
H. Dvinge +3 more
semanticscholar +1 more source