Results 111 to 120 of about 3,534,505 (378)
Crosstalk between m6A modification and alternative splicing during cancer progression
Clinical and Translational Medicine, 2023 Background N6‐methyladenosine (m6A), the most prevalent internal mRNA modification in eukaryotes, is added by m6A methyltransferases, removed by m6A demethylases and recognised by m6A‐binding proteins.
Zhi‐Man Zhu +4 more
doaj +1 more source
, 2021 ReviewThis entry is adapted from https://doi.org/10.3390/ijms21239032Alternative splicing (AS) is a critical post-transcriptional regulatory mechanism used by more than 95% of transcribed human genes and responsible for structural transcript variation ...
Jordan, Peter
core
Analysis of differential splicing suggests different modes of short-term splicing regulation [PDF]
arXiv, 2016 Motivation: Alternative splicing is an important mechanism in which the regions of pre-mRNAs are differentially joined in order to form different transcript isoforms. Alternative splicing is involved in the regulation of normal physiological functions but also linked to the development of diseases such as cancer.
arxiv
The Plant Cell, 2018 Genome-wide RNA-seq and mutant analyses reveal the importance of alternative splicing in the mineral deficiency response and in mineral uptake and remobilization in rice.
Chunlan Dong +11 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan +6 more
wiley +1 more source
A New Twist to Ibuprofen: Alternative Action in Alternative Splicing
European Medical Journal, 2019 Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and is a widely used medication. One indication of NSAID use is long-term chemoprevention to decrease the risk of developing various types of cancer, in particular colorectal cancer.
Peter Jordan +2 more
doaj
An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor [PDF]
, 2002 The human IGF-I gene has six exons, four of which are alternatively spliced. Variations in splicing involving exon 5 may occur, depending on the tissue type and hormonal environment.
Chew, S. L. +6 more
core +1 more source
Aberrant alternative splicing in breast cancer
Journal of Molecular Cell Biology, 2019 Alternative splicing is critical for human gene expression regulation, which plays a determined role in expanding the diversity of functional proteins.
Quan Yang +4 more
semanticscholar +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
Alternative Splicing and Transcription Elongation in Plants
Frontiers in Plant Science, 2019 Alternative splicing and transcription elongation by RNA polymerase II (RNAPII) are two processes which are tightly connected. Splicing is a co-transcriptional process, and different experimental approaches show that splicing is coupled to transcription ...
Micaela A. Godoy Herz +3 more
doaj +1 more source