Results 201 to 210 of about 411,790 (378)

Role of the branch site/3'-splice site region in adenovirus-2 E1A pre-mRNA alternative splicing: evidence for 5'- and 3'-splice site co-operation [PDF]

, 1989
Per Johan Ulfendahl, Jan‐Peter Kreivi, Göran Akusjärvi   +2 more
openalex   +1 more source

Origins, Dispersal, and Impact: Bidirectional Introgression Between Chinese and European Pig Populations

Advanced Science, Volume 12, Issue 22, June 12, 2025.
This study investigates bidirectional introgression between Chinese and European pig populations, revealing 3558 introgressed genomic segments and 30 structural variations. Analysis of the BMP2 region suggests its role in body size enhancement. By integrating ancient and modern genomes, the study highlights the impact of introgression on genetic ...
Yibin Qiu, Langqing Liu, Min Huang, Donglin Ruan, Rongrong Ding, Zebin Zhang, Enqin Zheng, Shiyuan Wang, Shaoxiong Deng, Xianglun Meng, Xinyan Cheng, Jiaxin Shi, Yingshan Yang, Fuchen Zhou, Sixiu Huang, Huaqiang Yang, Zicong Li, Gengyuan Cai, Zhenfang Wu, Jie Yang   +19 more
wiley   +1 more source

Coronavirus leader‐RNA‐primed transcription: An alternative mechanism to RNA splicing

, 1986
Michael M. C. Lai
openalex   +1 more source

Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair

Advanced Science, EarlyView.
CircGLIS3(2), a circRNA transiently upregulated in dermal fibroblasts during acute wound healing, is induced by IL‐1α and TGF‐β. Its RNA activates fibroblasts into matrix‐secreting cells, while its encoded protein enhances proliferation. The RNA stabilizes PCOLCE, and the protein interacts with BTF3, collectively accelerating wound repair. Abstract The
Guanglin Niu, Maria A. Toma, Jennifer Geara, Xiaowei Bian, Yongjian Chen, Lihua Luo, Qizhang Wang, Yunting Xiao, Manika Vij, Minna Piipponen, Zhuang Liu, Sho Oasa, Letian Zhang, Dörte Schlesinger, Ákos Végvári, Dongqing Li, Aoxue Wang, Vladana Vukojević, Simon J Elsässer, Pehr Sommar, Ning Xu Landén   +20 more
wiley   +1 more source

Magnetic‐Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models

Advanced Science, Volume 12, Issue 22, June 12, 2025.
Magnetic field‐guided MNP@ATR‐ASO nanocomplexes facilitate the targeted delivery of ASOs to ganglion cells or photoreceptors within retinal explants, thereby enhancing the efficacy of ASOs in correcting pre‐mRNA splicing abnormalities. Furthermore, the nanocomplexes improve ASO penetration and delivery in human retinal and inner ear organoid models ...
Xiuhong Ye, Sihui Chen, Wei Xiong, Fan Wang, Hon Fai Chan, Haocheng Lai, Xiangyu Guo, Tingting Yang, Shuhao Shen, Hang Chen, Wenxuan Wang, Guei‐Sheung Liu, Yonglong Guo, Jiansu Chen   +13 more
wiley   +1 more source

Alternative Splicing of the Platelet-Derived Growth Factor A-Chain Transcript Occurs in Normal as Well as Tumor Cells and Is Conserved among Mammalian Species [PDF]

, 1989
Brona Matoskova, Fredrik Rorsman, Viveka Svensson, Christer Betsholtz   +3 more
openalex   +1 more source

A Phase‐Separated SR Protein Reprograms Host Pre‐mRNA Splicing to Enhance Disease Susceptibility

Advanced Science, EarlyView.
This study identifies SR30, a splicing factor, as a negative regulator of tomato immunity. During Phytophthora infestans infection, the elevated SR30 forms nuclear condensates to suppress the alternative splicing (AS) of defense‐related genes in a phase separation manner.
Dong Yan, Jie Huang, Fengqi Tian, Haidong Shu, Han Chen, Qian Peng, Hongwei Wu, Jianlong Zhao, Anireddy S. N. Reddy, Gang Li, Yuanchao Wang, Suomeng Dong   +11 more
wiley   +1 more source

Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains dfffering in the number of internal repeats

, 1984
Alberto R. Kornblihtt, Karen Vibe‐Pedersen, Francisco E. Baralle   +2 more
openalex   +2 more sources

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

Advanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han   +10 more
wiley   +1 more source

Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene.

, 1988
Mark A. Thiede, Gordon J Strewler, Robert A. Nissenson, Michael Rosenblatt, Gideon A. Rodan   +4 more
openalex   +1 more source