Results 241 to 250 of about 326,335 (355)

Modulation of alternative splicing of adenoviral E1A transcripts: factors involved in the early-to-late transition. [PDF]

, 1991
Renata Gattoni, K. Chebli, Michèle Himmelspach, James Stévenin   +3 more
openalex   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

Alternative splicing and the aging brain in AfrAbia: New frontiers in dementia research. [PDF]

IBRO Neurosci Rep
Aremu SA.
europepmc   +1 more source

Developmentally regulated alternative splicing generates a complex array of Drosophila para sodium channel isoforms [PDF]

, 1994
J. R. Thackeray, Barry Ganetzky
openalex   +1 more source

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source

Alternative Splicing of Functional Genes in Plant Growth, Development, and Stress Responses. [PDF]

Int J Mol Sci
Liu G, Wang H, Gao H, Yu S, Liu C, Wang Y, Sun Y, Zhang D.   +7 more
europepmc   +1 more source

Human alpha 3(VI) collagen gene. Characterization of exons coding for the amino-terminal globular domain and alternative splicing in normal and tumor cells

, 1991
David G. Stokes, B. Saitta, Rupert Timpl, Mon‐Li Chu   +3 more
openalex   +1 more source

Functional analysis of alternatively spliced transcripts of the human histidine decarboxylase gene and its expression in human tissues and basophilic leukemia cells [PDF]

, 1992
Ruriko MAMUNE‐SATO, Kohei Yamauchi, Yasuo Tanno, Yuichi Ohkawara, Hiroshi Ohtsu, Dai Katayose, Kazutaka Maeyama, Takehiko Watanabe, Shigeki Shibahara, Tamotsu Takishima   +9 more
openalex   +1 more source

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

Advanced Science, EarlyView.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng, Jiayao Li, Wuke Wang, Dong Liang, Zhanwei Li, Cong Mao, Qingyang Li, Yu Zhang, Hao Chen, Jin Tang, Ping Hu, Qi Niu, Xingxu Huang, Bin Shen, Jun Zhang   +14 more
wiley   +1 more source

Epigenetic Regulation and Therapeutic Targeting of Alternative Splicing Dysregulation in Cancer. [PDF]

Pharmaceuticals (Basel)
Lei Y, Lai M.
europepmc   +1 more source