Single‐cell RNA sequencing identifies MMP11⁺ CAFs as pro‐angiogenic cells accumulating during bladder cancer progression. These cells promote angiogenesis by regulating ESM1⁺ tip endothelial cells and recruiting SPP1⁺ macrophages. Tumor‐derived BMP2 promotes their activation.
Wuwu Xu+13 more
wiley +1 more source
Regulated microexon alternative splicing in single neurons tunes synaptic function. [PDF]
Choudhary B, Napier-Jameson R, Norris A.
europepmc +1 more source
Occurrence of alternatively spliced leader-delta onc-poly(A) transcripts in chicken neuroretina cells infected with Rous-associated virus type 1: implication in transduction of the c-mil/c-raf and c-Rmil/B-raf oncogenes [PDF]
M P Felder+4 more
openalex +1 more source
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan+19 more
wiley +1 more source
Alternative splicing of squid is associated with sex-ratio allocation in the wasp Copidosomopsis nacoleiae. [PDF]
Ouyang H+5 more
europepmc +1 more source
Alternative splicing of a previously unidentified CFTR exon introduces an in‐frame stop codon 5' of the R region [PDF]
Carlos A. Melo+8 more
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SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong+9 more
wiley +1 more source
Alternative Splicing in Lung Adenocarcinoma: From Bench to Bedside. [PDF]
Luo W, Xu M, Wong N, Ng CS.
europepmc +1 more source
Snol, a novel alternatively spliced isoform of the ski protooncogene homolog, sno [PDF]
Sonia Pearson‐White
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