Results 81 to 90 of about 344,150 (327)

RBM10 regulates alternative splicing [PDF]

FEBS Letters, 2014
RBM10, originally called S1‐1, is a nuclear RNA‐binding protein with domains characteristic of RNA processing proteins. It has been reported that RBM10 constitutes spliceosome complexes and that RBM5, a close homologue of RBM10, regulates alternative splicing of apoptosis‐related genes, Fas and cFLIP.
Inoue, Akira, Yamamoto, Naoki, Kimura, Masatsugu, Nishio, Koji, Yamane, Hideo, Nakajima, Koichi   +5 more
openaire   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans [PDF]

, 2017
This is the final version of the article. Available from the publisher via the DOI in this record.Dysregulation of splicing factor expression and altered alternative splicing are associated with aging in humans and other species, and also with ...
Emond, F, Ferrucci, L, Flurkey, K, Harries, LW, Harrison, DE, Kuchel, GA, Lee, BP, Melzer, D, Peters, LL, Pilling, LC, Yuan, R   +10 more
core   +1 more source

Crosstalk between m6A modification and alternative splicing during cancer progression

Clinical and Translational Medicine, 2023
Background N6‐methyladenosine (m6A), the most prevalent internal mRNA modification in eukaryotes, is added by m6A methyltransferases, removed by m6A demethylases and recognised by m6A‐binding proteins.
Zhi‐Man Zhu, Fu‐Chun Huo, Jian Zhang, Hong‐Jian Shan, Dong‐Sheng Pei   +4 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Genome-wide analysis of alternative splicing events in Hordeum vulgare: highlighting retention of intron-based splicing and its possible function through network analysis [PDF]

, 2015
In this study, using homology mapping of assembled expressed sequence tags against the genomic data, we identified alternative splicing events in barley.
Ebrahimie, E., Fallah Mehrabadi, J., Khaksefidi, R., Mohammadi, S., Panahi, B.   +4 more
core   +1 more source

Combining genetic constraint with predictions of alternative splicing to prioritize deleterious splicing in rare disease studies

BMC Bioinformatics, 2022
Background Despite numerous molecular and computational advances, roughly half of patients with a rare disease remain undiagnosed after exome or genome sequencing.
Michael J. Cormier, Brent S. Pedersen, Pinar Bayrak-Toydemir, Aaron R. Quinlan   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A minor alternative transcript of the fumarylacetoacetate hydrolase gene produces a protein despite being likely subjected to nonsense-mediated mRNA decay [PDF]

, 2005
BACKGROUND: Coupling of alternative splicing with nonsense-mediated mRNA decay (NMD) may regulate gene expression. We report here the identification of a nonsense alternative transcript of the fumarylacetoacetate hydrolase (fah) gene, which produces a ...
Bergeron, Anne, Boisclair-Lachance, Jean-François, Dreumont, Natacha, Maresca, Antonella, Tanguay, Robert M   +4 more
core   +3 more sources

Therapeutic potential of alternative splicing in cardiovascular diseases

EBioMedicine
Summary: RNA splicing is an important RNA processing step required by multiexon protein-coding mRNAs and some noncoding RNAs. Precise RNA splicing is required for maintaining gene and cell function; however, mis-spliced RNA transcripts can lead to loss ...
Jun Cao, Ziyu Wei, Yu Nie, Hou-Zao Chen
doaj   +1 more source