Results 141 to 150 of about 261,784 (335)

The potential of multi-organ-on-chip models for assessment of drug disposition as alternative to animal testing

, 2021
Damiën van Berlo, Evita van de Steeg, Hossein Eslami Amirabadi, Rosalinde Masereeuw   +3 more
openalex   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Organ‐on‐Chip: The Future of Nutrition Research in a One Health World

Food Frontiers
The One Health approach emphasizes the interconnectedness of human, animal, and environmental health, recognizing that the health of each is interdependent and influenced by shared ecosystems.
Manuela Cassotta, Maria Elexpuru‐Zabaleta, Sandra Sumalla Cano, Yasmany Armas Diaz, Francesca Giampieri, Zou Xiaobo, Di Zhang, Giuseppe Grosso, Maurizio Battino   +8 more
doaj   +1 more source

Bioreactor analyses of tissue ingrowth, ongrowth and remodelling around implants: An alternative to live animal testing

, 2023
Nupur Kohli, Konstantinos Theodoridis, Thomas A. Hall, Inigo Sanz-Pena, David Gaboriau, Richard J. van Arkel   +5 more
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Human‐based new approach methodologies to accelerate advances in nutrition research

Food Frontiers
Much of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases as well as to ...
Manuela Cassotta, Danila Cianciosi, Maria Elexpuru‐Zabaleta, Inaki Elio Pascual, Sandra Sumalla Cano, Francesca Giampieri, Maurizio Battino   +6 more
doaj   +1 more source

Assessment of the Ocular Irritation Potential of Pesticides using Reconstructed Human Cornea-like Epithelium (RhCE) Model as Alternatives to Animal Testing [PDF]

, 2018
Youmi Jo, Ju‐Yeun Lee, Soo‐Jin Park, Are-Sun You, Jin A Oh, Je Bong Lee, Yeon-Ki Park, Mi-Hye Jeong   +7 more
openalex   +1 more source

2001 Consultation of organic farming research priorities in the UK [PDF]

, 2001
The following reports a consultation of organic farming research priorities in the UK in 2001. The information was collated by Organic Centre Wales, Institute of Rural Studies, University of Wales, Aberystwyth on behalf of MAFF organic farming unit and
Lampkin, Nic, Padel, Susanne, Powell, Jane   +2 more
core  

[Legal aspects of alternative methods to animal testing].

Biologie aujourd'hui, 2023
Si le remplacement total de l’expérimentation animale était l’objectif visé par la directive européenne du 22 septembre 2010 relative à la protection des animaux utilisés à des fins scientifiques, force est de constater qu’il est encore loin d’être atteint. Le nombre d’animaux ne diminue pas et les méthodes alternatives peinent à être utilisées.
openaire   +2 more sources