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Organoid intelligence for developmental neurotoxicity testing [PDF]
Frontiers in Cellular NeuroscienceThe increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determine developmental neurotoxicity (DNT) hazard for thousands of chemicals. This paper proposes the integration of organoid intelligence
Dowlette-Mary Alam El Din +9 more
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Stem cell-based approaches for developmental neurotoxicity testing [PDF]
Frontiers in ToxicologyNeurotoxicants are substances that can lead to adverse structural or functional effects on the nervous system. These can be chemical, biological, or physical agents that can cross the blood brain barrier to damage neurons or interfere with complex ...
Joy Ku, Prashanth Asuri
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The Role of Autophagy in Copper-Induced Apoptosis and Developmental Neurotoxicity in SH-SY5Y Cells [PDF]
ToxicsCopper (Cu) is a global environmental pollutant that poses a serious threat to humans and ecosystems. Copper induces developmental neurotoxicity, but the underlying molecular mechanisms are unknown.
Lu Lu +6 more
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Titanium Dioxide Nanoparticles Aggravated the Developmental Neurotoxicity of Ammonia Nitrogen on Zebrafish Embryos [PDF]
ToxicsTotal ammonia nitrogen (TAN) is a common and potent neurotoxic pollutant in aquatic environments. Due to their strong adsorption capacity, titanium dioxide nanoparticles (n-TiO2), a widely used engineered material, can induce combined toxicity with ...
Minglei Lyu +11 more
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Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons [PDF]
Environment InternationalPFOA is a legacy Per- and Polyfluorinated Substances (PFAS), a group of chemicals widely used in various industrial applications and consumer products.
Shichen Wu +7 more
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Frontiers in Molecular Biosciences, 2021 Lead (Pb) is among the deleterious heavy metal and has caused global health concerns due to its tendency to cause a detrimental effect on the development of the central nervous system (CNS).
Xiuna Ji +13 more
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Environment International, 2021 Limited studies on multi-omics have been conducted to comprehensively investigate the molecular mechanism underlying the developmental neurotoxicity of perfluorooctanesulfonic acid (PFOS).
Hyojin Lee +9 more
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Ecotoxicology and Environmental Safety, 2023 Fluoride is capable of inducing developmental neurotoxicity; regrettably, the mechanism is obscure. We aimed to probe the role of lysosomal biogenesis disorder in developmental fluoride neurotoxicity—specifically, the regulating effect of the transient ...
Jingjing Zhang +7 more
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Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish
Frontiers in Genetics, 2021 Adverse outcomes that result from chemical toxicity are rarely caused by dysregulation of individual proteins; rather, they are often caused by system-level perturbations in networks of molecular events. To fully understand the mechanisms of toxicity, it
Roman A. Li +9 more
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Ecotoxicology and Environmental Safety, 2022 Fluoride is capable of inducing developmental neurotoxicity, but the mechanisms involved remain unclear. We aimed to explore the role of autophagosome-lysosome fusion in developmental fluoride neurotoxicity, particularly focusing on the interaction ...
Yuanli Zhang +7 more
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