Results 11 to 20 of about 23,637 (256)

A developmental neurotoxicity adverse outcome pathway (DNT‐AOP) with voltage gate sodium channel (VGSC) inhibition as a molecular initiating event (MiE) [PDF]

EFSA Journal
The adverse outcome pathway (AOP) framework serves as a practical tool for organising scientific knowledge that can be used to infer cause–effect relationships between stressor events and toxicity outcomes in intact organisms.
European Food Safety Authority (EFSA), Kevin M. Crofton, Martin Paparella, Anna Price, Iris Mangas, Laura Martino, Andrea Terron, Antonio Hernández‐Jerez   +7 more
doaj   +2 more sources

Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy

Frontiers in Molecular Biosciences, 2021
Lead (Pb) is among the deleterious heavy metal and has caused global health concerns due to its tendency to cause a detrimental effect on the development of the central nervous system (CNS).
Xiuna Ji, Xiuna Ji, Baokun Wang, Baokun Wang, Yam Nath Paudel, Zhihui Li, Shanshan Zhang, Shanshan Zhang, Lei Mou, Lei Mou, Kechun Liu, Kechun Liu, Meng Jin, Meng Jin   +13 more
doaj   +1 more source

Integrated multi-omics analysis reveals the underlying molecular mechanism for developmental neurotoxicity of perfluorooctanesulfonic acid in zebrafish

Environment International, 2021
Limited studies on multi-omics have been conducted to comprehensively investigate the molecular mechanism underlying the developmental neurotoxicity of perfluorooctanesulfonic acid (PFOS).
Hyojin Lee, Eun Ji Sung, Seungwoo Seo, Eun Ki Min, Ji-Young Lee, Ilseob Shim, Pilje Kim, Tae-Young Kim, Sangkyu Lee, Ki-Tae Kim   +9 more
doaj   +1 more source

The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity

Ecotoxicology and Environmental Safety, 2023
Fluoride is capable of inducing developmental neurotoxicity; regrettably, the mechanism is obscure. We aimed to probe the role of lysosomal biogenesis disorder in developmental fluoride neurotoxicity—specifically, the regulating effect of the transient ...
Jingjing Zhang, Yanling Tang, Zeyu Hu, Wanjing Xu, Yue Ma, Panpan Xu, Hengrui Xing, Qiang Niu   +7 more
doaj   +1 more source

Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish

Frontiers in Genetics, 2021
Adverse outcomes that result from chemical toxicity are rarely caused by dysregulation of individual proteins; rather, they are often caused by system-level perturbations in networks of molecular events. To fully understand the mechanisms of toxicity, it
Roman A. Li, Roman A. Li, Marja Talikka, Sylvain Gubian, Colette vom Berg, Florian Martin, Manuel C. Peitsch, Julia Hoeng, Anze Zupanic, Anze Zupanic   +9 more
doaj   +1 more source

Prevention of Developmental Neurotoxicity [PDF]

Epidemiology, 2017
Accepted ...
Grandjean, Philippe, Kishi, Reiko, Kogevinas, Manolis   +2 more
openaire   +5 more sources

Weakened interaction of ATG14 and the SNARE complex blocks autophagosome-lysosome fusion contributes to fluoride-induced developmental neurotoxicity

Ecotoxicology and Environmental Safety, 2022
Fluoride is capable of inducing developmental neurotoxicity, but the mechanisms involved remain unclear. We aimed to explore the role of autophagosome-lysosome fusion in developmental fluoride neurotoxicity, particularly focusing on the interaction ...
Yuanli Zhang, Xie Han, Yanling Tang, Jingjing Zhang, Zeyu Hu, Wanjing Xu, Ping Yao, Qiang Niu   +7 more
doaj   +1 more source

PRKAA1 induces aberrant mitophagy in a PINK1/Parkin-dependent manner, contributing to fluoride-induced developmental neurotoxicity

Ecotoxicology and Environmental Safety, 2023
Chronic fluoride exposure can cause developmental neurotoxicity, however the precise mechanisms remain unclear. To explore the mechanism of mitophagy in fluoride-induced developmental neurotoxicity, specifically focusing on PRKAA1 in regulating the PINK1/
Yanling Tang, Jingjing Zhang, Zeyu Hu, Wanjing Xu, Panpan Xu, Yue Ma, Hengrui Xing, Qiang Niu   +7 more
doaj   +1 more source

Manganese and Developmental Neurotoxicity [PDF]

, 2017
Manganese (Mn) is an essential metal that plays a fundamental role for brain development and functioning. Environmental exposure to Mn may lead to accumulation in the basal ganglia and development of Parkinson-like disorders. The most recent research is focusing on early-life overexposure to Mn and the potential vulnerability of younger individuals to ...
LUCCHINI, Roberto, PLACIDI, Donatella, CAGNA, Giuseppa, FEDRIGHI, Chiara, OPPINI, Manuela, PELI, Marco, ZONI, Silvia   +6 more
openaire   +4 more sources

The Developmental Neurotoxicity of Arsenic: Cognitive and Behavioral Consequences of Early Life Exposure

Annals of Global Health, 2014
Background: More than 200 million people worldwide are chronically exposed to arsenic. Arsenic is a known human carcinogen, and its carcinogenic and systemic toxicity have been extensively studied.
Molly Tolins, Mathuros Ruchirawat, Philip Landrigan   +2 more
doaj   +1 more source