Results 11 to 20 of about 25,080 (259)

Developmental fluoride neurotoxicity: an updated review [PDF]

Environmental Health, 2019
Background After the discovery of fluoride as a caries-preventing agent in the mid-twentieth century, fluoridation of community water has become a widespread intervention, sometimes hailed as a mainstay of modern public health.
Philippe Grandjean
doaj   +4 more sources

Methylmercury exposure and developmental neurotoxicity

Bulletin of the World Health Organization, 2014
We are concerned that certain aspects of the systematic review on methylmercury (MeHg) exposure from seafood consumption and the risk of developmental neurotoxicity published in the Bulletin of World Health Organization could be misinterpreted.1 Specifically, the review does not address the issue of whether naturally-occurring, background levels of ...
Gary J Myers, Philip W Davidson, Gene E Watson, Edwin van Wijngaarden, Sally W Thurston, JJ Strain, Conrad F Shamlaye, Pascal Bovet   +7 more
doaj   +6 more sources

Prevention of Developmental Neurotoxicity [PDF]

Epidemiology, 2017
Accepted ...
Grandjean, Philippe, Kishi, Reiko, Kogevinas, Manolis   +2 more
openaire   +5 more sources

Manganese and Developmental Neurotoxicity [PDF]

, 2017
Manganese (Mn) is an essential metal that plays a fundamental role for brain development and functioning. Environmental exposure to Mn may lead to accumulation in the basal ganglia and development of Parkinson-like disorders. The most recent research is focusing on early-life overexposure to Mn and the potential vulnerability of younger individuals to ...
LUCCHINI, Roberto, PLACIDI, Donatella, CAGNA, Giuseppa, FEDRIGHI, Chiara, OPPINI, Manuela, PELI, Marco, ZONI, Silvia   +6 more
openaire   +4 more sources

PRKAA1 induces aberrant mitophagy in a PINK1/Parkin-dependent manner, contributing to fluoride-induced developmental neurotoxicity

Ecotoxicology and Environmental Safety, 2023
Chronic fluoride exposure can cause developmental neurotoxicity, however the precise mechanisms remain unclear. To explore the mechanism of mitophagy in fluoride-induced developmental neurotoxicity, specifically focusing on PRKAA1 in regulating the PINK1/
Yanling Tang, Jingjing Zhang, Zeyu Hu, Wanjing Xu, Panpan Xu, Yue Ma, Hengrui Xing, Qiang Niu   +7 more
doaj   +1 more source

Developmental Neurotoxicity of Difenoconazole in Zebrafish Embryos

Toxics, 2023
Difenoconazole is a type of triazole fungicide that is widely used in the treatment of plant diseases. Triazole fungicides have been shown in several studies to impair the development of the nervous system in zebrafish embryos.
Qing Yang, Ping Deng, Dan Xing, Haoling Liu, Fang Shi, Lian Hu, Xi Zou, Hongyan Nie, Junli Zuo, Zimeng Zhuang, Meiqi Pan, Juan Chen, Guangyu Li   +12 more
doaj   +1 more source

The Developmental Neurotoxicity of Arsenic: Cognitive and Behavioral Consequences of Early Life Exposure

Annals of Global Health, 2014
Background: More than 200 million people worldwide are chronically exposed to arsenic. Arsenic is a known human carcinogen, and its carcinogenic and systemic toxicity have been extensively studied.
Molly Tolins, Mathuros Ruchirawat, Philip Landrigan   +2 more
doaj   +1 more source

Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity

Ecotoxicology and Environmental Safety, 2022
Fluoride is capable of inducing developmental neurotoxicity, yet its mechanisms remain elusive. We aimed to explore the possible role and mechanism of autophagic flux blockage caused by abnormal lysosomal pH in fluoride-induced developmental ...
Xie Han, Yanling Tang, Yuanli Zhang, Jingjing Zhang, Zeyu Hu, Wanjing Xu, Shangzhi Xu, Qiang Niu   +7 more
doaj   +1 more source

Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

Frontiers in Cellular Neuroscience, 2020
Selective serotonin reuptake inhibitors (SSRIs) are frequently used to treat depression during pregnancy. Various concerns have been raised about the possible effects of these drugs on fetal development.
Xiali Zhong, Xiali Zhong, Georgina Harris, Lena Smirnova, Valentin Zufferey, Rita de Cássia da Silveira e Sá, Fabiele Baldino Russo, Patricia Cristina Baleeiro Beltrao Braga, Patricia Cristina Baleeiro Beltrao Braga, Megan Chesnut, Marie-Gabrielle Zurich, Helena T. Hogberg, Thomas Hartung, Thomas Hartung, David Pamies, David Pamies   +15 more
doaj   +1 more source

Caenorhabditis elegans Neurotoxicity Testing: Novel Applications in the Adverse Outcome Pathway Framework

Frontiers in Toxicology, 2022
Neurological hazard assessment of industrial and pesticidal chemicals demands a substantial amount of time and resources. Caenorhabditis elegans is an established model organism in developmental biology and neuroscience.
Shreesh Raj Sammi, Shreesh Raj Sammi, Laura E. Jameson, Kendra D. Conrow, Maxwell C. K. Leung, Jason R. Cannon, Jason R. Cannon   +6 more
doaj   +1 more source