Critical complications in cancer patients admitted to the ICU in the era of immunotherapy: recognition, differential diagnosis, and management [PDF]
Frontiers in MedicineBackgroundImmunotherapy has introduced a new spectrum of ICU-relevant complications in patients with cancer, including hyperinflammatory syndromes, neurotoxicity, severe pneumonitis, myocarditis, and overlapping infectious complications.ObjectiveTo ...
Di Wang, Min Yu
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The role of neuroimaging in neurotoxicity after chimeric antigen receptor T-cell therapy [PDF]
Therapeutic Advances in Neurological DisordersChimeric antigen receptor T-cell (CAR-T) therapy has become an established treatment for several haematological malignancies in relapse and is being evaluated for new indications.
Arian Lasocki +3 more
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Chemotherapy-Induced Neurotoxicity: Molecular Mechanisms, Biomarkers and Emerging Neuroprotective Strategies [PDF]
BiomedicinesChemotherapy-induced neurotoxicity is a major dose-limiting complication of systemic anticancer therapy that adversely affects neurological function, treatment continuity, and long-term quality of life among cancer survivors.
Saahil A. Singh +4 more
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The neurotoxic legacy of CAR-T cells: where do we stand? [PDF]
Therapeutic Advances in Neurological DisordersChimeric antigen receptor T (CAR-T) cell therapy has transformed outcomes for relapsed/refractory B-cell malignancies and is increasingly reshaping the therapeutic landscape of autoimmune disorders and solid tumors, offering curative potential where ...
Simona Pagliuca +3 more
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Frontiers in Neurology, 2022 Cancer immunotherapy represents a novel anticancer strategy that acts directly on the immune system, promoting its activation toward cancer cells to enhance its natural ability to fight cancer.
Umberto Pensato +2 more
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Effect of chemotherapy on effect-site concentration of propofol for loss of consciousness in patients with colorectal cancer [PDF]
Korean Journal of Anesthesiology, 2022 Background The depth of anesthesia is an essential factor in surgical prognosis. The neurotoxic effect of chemotherapeutic drugs affects the sensitivity to anesthetics.
Seunghee Ki +5 more
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Bilirubin-Induced Transcriptomic Imprinting in Neonatal Hyperbilirubinemia
Biology, 2023 Recent findings indicated aberrant epigenetic control of the central nervous system (CNS) development in hyperbilirubinemic Gunn rats as an additional cause of cerebellar hypoplasia, the landmark of bilirubin neurotoxicity in rodents.
John Paul Llido +7 more
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Medicina U.P.B., 2020 Caso clínico de un hombre de 20 años, procedente de área rural de un municipio de Nariño, que consulta a un centro de salud después de 36 horas de haber ingerido de modo no intencional 20-30 mL de gramoxone (dicloruro de paraquat) mientras estaba en ...
Andrés Camilo Rivera Ordóñez +2 more
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Lipid Emulsion in the Successful Resuscitation of Local Anesthetic Toxicity after Ankle Block [PDF]
Korean Journal of Critical Care Medicine, 2014 Unexpected occurrence of local anesthetic toxicity is not rare and can cause fatal complications that do not respond to any known drug of intervention.
Sang Hee Park +5 more
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C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning [PDF]
Acta Cirúrgica Brasileira, 2020 Purpose Studies have demonstrated that star fruit consumption by nephropathic patients triggers severe neurotoxic effects that can lead to convulsions or even death. Brain areas likely susceptible to star fruit poisoning have not been investigated.
Renato Figueiredo Santana +5 more
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