Results 21 to 30 of about 23,637 (256)

Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity

Ecotoxicology and Environmental Safety, 2022
Fluoride is capable of inducing developmental neurotoxicity, yet its mechanisms remain elusive. We aimed to explore the possible role and mechanism of autophagic flux blockage caused by abnormal lysosomal pH in fluoride-induced developmental ...
Xie Han, Yanling Tang, Yuanli Zhang, Jingjing Zhang, Zeyu Hu, Wanjing Xu, Shangzhi Xu, Qiang Niu   +7 more
doaj   +1 more source

Neurogenesis and developmental anesthetic neurotoxicity [PDF]

Neurotoxicology and Teratology, 2017
The mechanism by which anesthetics might act on the developing brain in order to cause long term deficits remains incompletely understood. The hippocampus has been identified as a structure that is likely to be involved, as rodent models show numerous deficits in behavioral tasks of learning that are hippocampal-dependent. The hippocampus is an unusual
Eunchai, Kang, Daniel A, Berg, Orion, Furmanski, William M, Jackson, Yun Kyoung, Ryu, Christy D, Gray, C David, Mintz   +6 more
openaire   +2 more sources

Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

Frontiers in Cellular Neuroscience, 2020
Selective serotonin reuptake inhibitors (SSRIs) are frequently used to treat depression during pregnancy. Various concerns have been raised about the possible effects of these drugs on fetal development.
Xiali Zhong, Xiali Zhong, Georgina Harris, Lena Smirnova, Valentin Zufferey, Rita de Cássia da Silveira e Sá, Fabiele Baldino Russo, Patricia Cristina Baleeiro Beltrao Braga, Patricia Cristina Baleeiro Beltrao Braga, Megan Chesnut, Marie-Gabrielle Zurich, Helena T. Hogberg, Thomas Hartung, Thomas Hartung, David Pamies, David Pamies   +15 more
doaj   +1 more source

Caenorhabditis elegans Neurotoxicity Testing: Novel Applications in the Adverse Outcome Pathway Framework

Frontiers in Toxicology, 2022
Neurological hazard assessment of industrial and pesticidal chemicals demands a substantial amount of time and resources. Caenorhabditis elegans is an established model organism in developmental biology and neuroscience.
Shreesh Raj Sammi, Shreesh Raj Sammi, Laura E. Jameson, Kendra D. Conrow, Maxwell C. K. Leung, Jason R. Cannon, Jason R. Cannon   +6 more
doaj   +1 more source

Effects of Maternal Exposure to Decamethylcyclopentasiloxane on the Alternations in Offspring Behaviors in Mice

Biomedicines, 2022
D5, a member of the cyclic siloxane family, is widely used in personal care products such as shampoo, cosmetics, and deodorant and as an industrial intermediate. D5 can mainly be absorbed orally or through inhalation.
Donglin Yi, Kangmin Kim, Minsu Lee, Eui-man Jung, Eui-Bae Jeung   +4 more
doaj   +1 more source

Histo-anatomical mutilations of developing chick brain induced by in-ovo fluoride and bifenthrin exposure

Toxicology Reports, 2023
Comparative developing brain histo-anatomical pathologies of Fluoride ions and Bifenthrin in-ovo exposures were explored in the golden black variety of domestic chick. Three exposure groups were –the Vehicle control group (Vg); Fluoride (F) group and the
Ayesha Faisal, Zubedah Khanum, Syeda Nadia Ahmad, Khawaja Raees Ahmad, Asma Younis, Sadia Suleman, Iram Inayat, Muhammad Ali Kanwal   +7 more
doaj   +1 more source

Differentiated Neurons Are More Vulnerable to Organophosphate and Carbamate Neurotoxicity than Undifferentiated Neurons Due to the Induction of Redox Stress and Accumulate Oxidatively-Damaged Proteins

Brain Sciences, 2023
Organophosphate (OP) and carbamate pesticides are toxic to pests through targeted inhibition of acetylcholinesterase (AChE). However, OPs and carbamates may be harmful to non-target species including humans and could induce developmental neurotoxicity if
Anusha W. Mudyanselage, Buddhika C. Wijamunige, Artur Kocon, Wayne G. Carter   +3 more
doaj   +1 more source

Differences in neurotoxic outcomes of organophosphorus pesticides revealed via multi-dimensional screening in adult and regenerating planarians

Frontiers in Toxicology, 2022
Organophosphorus pesticides (OPs) are a chemically diverse class of commonly used insecticides. Epidemiological studies suggest that low dose chronic prenatal and infant exposures can lead to life-long neurological damage and behavioral disorders.
Danielle Ireland, Siqi Zhang, Veronica Bochenek, Jui-Hua Hsieh, Christina Rabeler, Zane Meyer, Zane Meyer, Eva-Maria S. Collins, Eva-Maria S. Collins, Eva-Maria S. Collins, Eva-Maria S. Collins, Eva-Maria S. Collins   +11 more
doaj   +1 more source

Clearing the Air on Pollutant Disruptions of the Gut–Brain Axis: Developmental Exposure to Benzo[a]pyrene Disturbs Zebrafish Behavior and the Gut Microbiome in Adults and Subsequent Generations

Toxics
Developmental exposure to benzo[a]pyrene (BaP), a ubiquitous environmental pollutant, has been linked to various toxic effects, including multigenerational behavioral impairment.
Alexandra Alexiev, Ebony Stretch, Kristin D. Kasschau, Lindsay B. Wilson, Lisa Truong, Robyn L. Tanguay, Thomas J. Sharpton   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source