Results 1 to 10 of about 5,939 (122)

Chicken CH25H inhibits ALV-J replication by promoting cellular autophagy [PDF]

Frontiers in Immunology, 2023
Autophagy plays an important role in host antiviral defense. The avian leukosis virus subgroup J (ALV-J) has been shown to inhibit autophagy while promoting viral replication. The underlying autophagic mechanisms, however, are unknown.
Tingting Xie, Tingting Xie, Tingting Xie, Min Feng, Xi Zhang, Xi Zhang, Xi Zhang, Xiaoqi Li, Xiaoqi Li, Xiaoqi Li, Guodong Mo, Guodong Mo, Guodong Mo, Meiqing Shi, Xiquan Zhang, Xiquan Zhang, Xiquan Zhang   +16 more
doaj   +2 more sources

The tyrosine phosphatase SHP-2 dephosphorylated by ALV-J via its Env efficiently promotes ALV-J replication [PDF]

Virulence, 2021
Avian leukosis virus subgroup J (ALV-J) generally induces hemangioma, myeloid leukosis, and immunosuppression in chickens, causing significant poultry industry economic losses worldwide. The unusual env gene of ALV-J, with low homology to other subgroups
Tuofan Li, Jing Xie, Xiaohui Yao, Jun Zhang, Chunping Li, Dan Ren, Luyuan Li, Quan Xie, Hongxia Shao, Aijian Qin, Jianqiang Ye   +10 more
doaj   +2 more sources

CCL4 participates in the reprogramming of glucose metabolism induced by ALV-J infection in chicken macrophages. [PDF]

Front Microbiol, 2023
Interferon and chemokine-mediated immune responses are two general antiviral programs of the innate immune system in response to viral infections and have recently emerged as important players in systemic metabolism.
Wu H, Zaib G, Luo H, Guo W, Wu T, Zhu S, Wang C, Chai W, Xu Q, Cui H, Hu X.   +10 more
europepmc   +3 more sources

SOCS3 Promotes ALV-J Virus Replication via Inhibiting JAK2/STAT3 Phosphorylation During Infection [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that causes immunosuppression and neoplastic diseases in poultry. Cytokine signal-transduction inhibitor molecule 3 (SOCS3) is an important negative regulator of the JAK2/STAT3 signaling ...
Guodong Mo, Guodong Mo, Huali Fu, Huali Fu, Bowen Hu, Bowen Hu, Qihong Zhang, Qihong Zhang, Mingjian Xian, Mingjian Xian, Zihao Zhang, Zihao Zhang, Ling Lin, Ling Lin, Meiqing Shi, Qinghua Nie, Qinghua Nie, Xiquan Zhang, Xiquan Zhang   +18 more
doaj   +2 more sources

ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway [PDF]

Frontiers in Immunology, 2021
J subgroup avian leukosis virus (ALV-J) infection causes serious immunosuppression problems, leading to hematopoietic malignancy tumors in chicken.
Qihong Zhang, Qihong Zhang, Qihong Zhang, Tingting Xie, Tingting Xie, Tingting Xie, Guodong Mo, Guodong Mo, Guodong Mo, Zihao Zhang, Zihao Zhang, Zihao Zhang, Ling Lin, Ling Lin, Ling Lin, Xiquan Zhang, Xiquan Zhang, Xiquan Zhang   +17 more
doaj   +2 more sources

A Genetically Engineered Commercial Chicken Line Is Resistant to Highly Pathogenic Avian Leukosis Virus Subgroup J [PDF]

Microorganisms, 2021
Viral diseases remain a major concern for animal health and global food production in modern agriculture. In chickens, avian leukosis virus subgroup J (ALV-J) represents an important pathogen that causes severe economic loss.
Ahmed Kheimar, Romina Klinger, Luca D. Bertzbach, Hicham Sid, You Yu, Andelé M. Conradie, Benjamin Schade, Brigitte Böhm, Rudolf Preisinger, Venugopal Nair, Benedikt B. Kaufer, Benjamin Schusser   +11 more
doaj   +3 more sources

gga-miR-148a-5p-Targeting PDPK1 Inhibits Proliferation and Cell Cycle Progression of Avain Leukosis Virus Subgroup J (ALV-J)-Infected Cells [PDF]

Frontiers in Cell and Developmental Biology, 2020
Avian leukosis virus subgroup J disease (ALV-J) is a contagious and immunosuppressive avian disease caused by ALV-J virus. Although miRNA participate in various biological processes of tumors, little is known about the potential role of miRNA in ALV-J ...
Heling Yu, Hengyong Xu, Chaoyang Yan, Shiliang Zhu, Xi Lan, Yuxiang Lu, Qijian He, Huadong Yin, Qing Zhu, Xiaoling Zhao, Diyan Li, Yiping Liu, Yan Wang   +12 more
doaj   +2 more sources

Differential DNA Methylation and Gene Expression Between ALV-J-Positive and ALV-J-Negative Chickens [PDF]

Frontiers in Veterinary Science, 2021
Background: Avian leukosis virus subgroup J (ALV-J) is an oncogenic virus that causes serious economic losses in the poultry industry; unfortunately, there is no effective vaccine against ALV-J.
Yiming Yan, Yiming Yan, Yiming Yan, Huihua Zhang, Shuang Gao, Shuang Gao, Shuang Gao, Huanmin Zhang, Xinheng Zhang, Xinheng Zhang, Xinheng Zhang, Weiguo Chen, Weiguo Chen, Weiguo Chen, Wencheng Lin, Wencheng Lin, Wencheng Lin, Qingmei Xie, Qingmei Xie, Qingmei Xie   +19 more
doaj   +2 more sources

Revealing novel and conservative CD8+T-cell epitopes with MHC B2 restriction on ALV-J [PDF]

Veterinary Research
MHC B2 haplotype chickens have been reported to induce strong immune response against various avian pathogens. However, little is known about the CD8+T-cell epitope with MHC B2-restricted on subgroup J avian leukosis virus (ALV-J).
Xueqing Li, Ziwei Li, Mulin Ma, Na Yang, Shanyao Du, Ming Liao, Manman Dai   +6 more
doaj   +2 more sources

Sequence analysis for the complete proviral genome of subgroup J Avian Leukosis virus associated with hemangioma: a special 11 bp deletion was observed in U3 region of 3'UTR [PDF]

Virology Journal, 2011
Background Avian Leukosis virus (ALV) of subgroup J (ALV-J) belong to retroviruses, which could induce tumors in domestic and wild birds. Myelocytomatosis was the most common neoplasma observed in infected flocks; however, few cases of hemangioma caused ...
Zou Nianli, Lin Yan, Zhao Yang, Liu Cheng, Tian Mingxing, Shi Min, Liu Ping, Huang Yong   +7 more
doaj   +4 more sources