Results 31 to 40 of about 6,017 (174)

GH inhibits ALV-J replication and restricts cell cycle by activating PI3K/Akt signaling pathway. [PDF]

Poult Sci
Growth hormone (GH) plays a crucial role in growth, sexual maturity, and immunity in chickens. Avian leukosis virus subgroup J (ALV-J) is an exogenous tumorigenic retrovirus that primarily induces immunosuppression, growth retardation, decreased egg production, tumors formation, and even death in chickens.
Xia J, Lin L, Ju R, Xu C, Mo G, Zhang X.
europepmc   +4 more sources

ALV-miRNA-p19-01 Promotes Viral Replication via Targeting Dual Specificity Phosphatase 6

Viruses, 2022
MicroRNAs (miRNAs) are a group of regulatory noncoding RNAs, serving as major regulators with a sequence-specific manner in multifarious biological processes.
Yiming Yan, Sheng Chen, Liqin Liao, Shuang Gao, Yanling Pang, Xinheng Zhang, Huanmin Zhang, Qingmei Xie   +7 more
doaj   +1 more source

3'UTR of ALV-J can affect viral replication through promoting transcription and mRNA nuclear export. [PDF]

J Virol, 2023
ABSTRACT 3′ Untranslated regions (3′UTRs) play a crucial role in gene transcription and post-transcriptional regulation. During the past 30 years, subgroup J avian leukosis virus (ALV-J) had accumulated large-scale mutations in 3′UTRs of their proviral genome. In this study, we summarize five kinds of mutant 3′UTRs in ALV-J and analyzed their
Xu M, Qian K, Shao H, Yao Y, Nair V, Ye J, Qin A.   +6 more
europepmc   +3 more sources

Novel Function of Avian p53 in Binding to ALV-J LTR Contributes to Its Antiviral Roles. [PDF]

mBio, 2022
Rous sarcoma virus (RSV)/ALV was the first retrovirus to be discovered, which was really the first hint that cancer, or a tumor, could be transmitted by a virus. The specific mechanisms that regulate ALV replication during infection remain poorly understood.
Duan Y, Cao L, Yuan C, Suo X, Kong X, Gao Y, Li X, Zheng H, Wang X, Wang Q.   +9 more
europepmc   +4 more sources

Acquiring Resistance Against a Retroviral Infection via CRISPR/Cas9 Targeted Genome Editing in a Commercial Chicken Line [PDF]

, 2020
Genome editing technology provides new possibilities for animal breeding and aid in understanding host-pathogen interactions. In poultry, retroviruses display one of the most difficult pathogens to control by conventional strategies such as vaccinations.
Bartsch, Denise, Bertzbach, Luca D., Flisikowski, Krzysztof, Hellmich, Romina, Kaufer, Benedikt B., Lengyel, Kamila, Nair, Venugopal, Preisinger, Rudolf, Schlickenrieder, Antonina, Schusser, Benjamin, Sid, Hicham, Thoma, Theresa   +11 more
core   +1 more source

Avian Leukosis Virus Type J (ALV-J) in the Czech Republic [PDF]

Acta Veterinaria Brno, 2000
The paper describes the first occurrence of myelocytomatosis in the Czech Republic. A group of hens from the breeding flocks of the meat type aged 27 and 50 weeks with increased mortality and tumorous disease occurrence was examined. Necropsy and pathohistology proved myelocytomatosis. The presence of the ALV subtype J virus was proved using PCR.
J. Geryk, J. Svoboda, L. Kulíková, R. Halouzka, V. Jurajda   +4 more
core   +3 more sources

Deciphering Immune Modulation in Chickens Co-Infected with ALV-J and CIAV: A Transcriptomic Approach. [PDF]

Microorganisms
Viral co-infections pose significant challenges, causing substantial economic losses worldwide in the poultry industry. Among these, avian lLeukosis virus subgroup J (ALV-J) and chicken infectious anemia virus (CIAV) are particularly concerning, as they frequently lead to co-infections in chickens, further compromising their immune defenses, increasing
Chen S, Xu H, Li W, Nie Y, Xie Q, Chen W.   +5 more
europepmc   +4 more sources

Phylogenetic Analysis of ALV-J Associated with Immune Responses in Yellow Chicken Flocks in South China. [PDF]

Mediators Inflamm, 2021
The aim of this study was to better understand the sequence characteristics and immune responses in avian leukosis virus subgroup J (ALV‐J) infected yellow chicken flocks in South China. We isolated four strains of ALV‐J virus from these flocks, which were then identified by several methods, including subtype‐specific polymerase chain reaction (PCR ...
Zhang Q, Mo G, Xie T, Zhang Z, Fu H, Wei P, Zhang X.   +6 more
europepmc   +5 more sources

dPRLR causes differences in immune responses between early and late feathering chickens after ALV-J infection. [PDF]

Vet Res, 2022
AbstractTo understand the differences in immune responses between early feathering (EF) and late feathering (LF) chickens after infection with avian leukosis virus, subgroup J (ALV-J), we monitored the levels of prolactin, growth hormone and the immunoglobulins IgG and IgM in the serum of LF and EF chickens for 8 weeks.
Mo G, Hu B, Zhang Q, Ruan Z, Li W, Liang J, Shen Y, Mo Z, Zhang Z, Wu Z, Shi M, Zhang X.   +11 more
europepmc   +5 more sources

The Distribution and Localization of Collagen Triple Helix Repeat Containing-1 in Naturally and Experimentally Avian Leukosis Virus Subgroup J-Infected Chickens

Frontiers in Veterinary Science, 2020
Collagen triple helix repeat containing-1 (CTHRC1) has recently been identified as avian leukosis virus subgroup J (ALV-J) replication-dependent factor that remarkably facilitates ALV-J replication via interaction with the envelope glycoprotein (SU) of ...
Yu Pang, Defang Zhou, Jing Zhou, Jingwen Xue, Yiya Wang, Ziqiang Cheng   +5 more
doaj   +1 more source