Results 121 to 130 of about 1,184,873 (292)

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice

Stem Cell Reports, 2018
Summary: Induced pluripotent stem cell (iPSC)-derived hematopoietic cells represent a highly attractive source for cell and gene therapy. Given the longevity, plasticity, and self-renewal potential of distinct macrophage subpopulations, iPSC-derived ...
Adele Mucci, Elena Lopez-Rodriguez, Miriam Hetzel, Serena Liu, Takuji Suzuki, Christine Happle, Mania Ackermann, Henning Kempf, Roman Hillje, Jessica Kunkiel, Ewa Janosz, Sebastian Brennig, Silke Glage, Jens P. Bankstahl, Sabine Dettmer, Thomas Rodt, Gudrun Gohring, Bruce Trapnell, Gesine Hansen, Cole Trapnell, Lars Knudsen, Nico Lachmann, Thomas Moritz   +22 more
doaj   +1 more source

Pulmonary Transplantation of Human Induced Pluripotent Stem Cell‐derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis

American Journal of Respiratory and Critical Care Medicine, 2018
&NA; Rationale: Although the transplantation of induced pluripotent stem cell (iPSC)‐derived cells harbors enormous potential for the treatment of pulmonary diseases, in vivo data demonstrating clear therapeutic benefits of human iPSC‐derived cells in ...
C. Happle, N. Lachmann, M. Ackermann, Anja Mirenska, G. Göhring, K. Thomay, A. Mucci, M. Hetzel, Torsten Glomb, Takuji Suzuki, C. Chalk, S. Glage, O. Dittrich‐Breiholz, B. Trapnell, T. Moritz, G. Hansen   +15 more
semanticscholar   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Alveolar macrophages in patients with pulmonary tuberculosis [PDF]

, 1988
Total and HLA-DR positive alveolar macrophages were enumerated in the broncho-alveolar lavage fluids of active pulmonary tuberculosis, inactive pulmonary tuberculosis (treated cases), nontuberculous lung disease patients and normal healthy individuals.
Narayanan, P R, Selvaraj, P, Prabhakar, R, Venkataprasad, N, Vijayan, V K   +4 more
core   +1 more source

Functional studies on iron-laden alveolar macrophages Part I. Functions of alveolar macrophages in lung diseases, especially arc welder's lung [PDF]

, 1983
Alveolar macrophages are essential components of pulmonary defense. They are unique among mononuclear phagocytes in having direct exposure to inhaled microorganisms and environmental toxins and in their metabolic adaptations to the aerobic environment ...
Irie, Seiji
core  

Liquid Gallium Nanozyme Coatings Enable Sustained Nitric Oxide Generation With Antioxidant and Anti‐Inflammatory Functions

Advanced Science, EarlyView.
Liquid gallium (Ga) acts as a catalytic center for nitric oxide (NO) generation within a tannic acid–zirconium metal–phenolic network coating. Stabilized Ga nanoparticles catalyze S‐nitrosothiol decomposition through surface electron transfer, enabling controlled NO production, enhancing endothelial biocompatibility, and providing antioxidant and anti ...
Franco Centurion, Kang Lin, Shu Geng, Siti Nur Asyura Adzlan, Qingqing Fan, Federico Mazur, Ravindra Kokate, Priyank Kumar, Christina Cortez‐Jugo, Frank Caruso, Rona Chandrawati   +10 more
wiley   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis [PDF]

, 2012
peer-reviewedBackground Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cell types to encounter M.
Karsten Hokamp (42210), Magee, David A, Conlon, Kevin M., Park Stephen D. E., Gordon, Stephen V, Karsten Hokamp, David J. Lynn (107188), Conlon Kevin M., Lynn, David J, Taraktsoglou, Maria, Nicolas C Nalpas, Stephen D. E. Park (183071), Stephen V Gordon, Stephen V. Gordon (108974), MacHugh David E., Gordon Stephen V., Eamonn Gormley (84870), Nalpas Nicolas C., Nicolas C. Nalpas (183064), David A. Magee (183048), Killick, Kate E, John A Browne, MacHugh, David E, Nalpas, Nicolas C., Kate E Killick, David E MacHugh, Gormley, Eamonn, Lynn David J., David E. MacHugh (183089), Park, Stephen D. E., Hokamp, Karsten, David J Lynn, Maria Taraktsoglou (183055), Browne John A., Killick Kate E., Kevin M Conlon, Kevin M. Conlon (183076), Eamonn Gormley, Gormley Eamonn, David A Magee, Taraktsoglou Maria, Kate E. Killick (183061), Hokamp Karsten, Magee David A., Browne, John A, Stephen D E Park, Maria Taraktsoglou, John A. Browne (183068)   +47 more
core   +2 more sources

Pulmonary granulocyte influx and impaired alveolar macrophage adenylyl cyclase responsiveness in developing respiratory distress

Mediators of Inflammation, 1993
Alveolar macrophages have recently been postulated as being involved in the aetiology of adult respiratory distress syndrome (ARDS). To evaluate their role, basal cyclic AMP levels and responsiveness of adenylyl cyclase alveolar macrophages were ...
J. G. C. van Amsterdam, R. M. J. L. van der Heijde, H. P. Grotjohan, F. D. Beusenberg   +3 more
doaj   +1 more source