Results 1 to 10 of about 331,012 (291)
PPARs in Alveolar Macrophage Biology [PDF]
PPAR Research, 2007 PPARs, most notably PPAR-γ, play a crucial role in regulating the activation of alveolar macrophages, which in turn occupy a pivotal place in the immune response to pathogens and particulates drawn in with inspired air.
Monica R. Smith +2 more
doaj +5 more sources
Airway allergy causes alveolar macrophage death, profound alveolar disorganization and surfactant dysfunction [PDF]
Frontiers in Immunology, 2023 Respiratory disorders caused by allergy have been associated to bronchiolar inflammation leading to life-threatening airway narrowing. However, whether airway allergy causes alveolar dysfunction contributing to the pathology of allergic asthma remains ...
Lidia Feo-Lucas +18 more
doaj +2 more sources
Alveolar macrophage carbon is associated with COPD severity [PDF]
ERJ Open ResearchBackground COPD is driven by the inhalation of noxious particles. A significant component of particulate matter is carbon, which is taken up by alveolar macrophages.
James Baker +5 more
doaj +2 more sources
Ecotoxicology and Environmental Safety, 2021 The present study investigates whether paraquat (PQ) regulates polarization of alveolar macrophages through glycolysis and promotes the occurrence of acute lung injury in rats.
Tong-Wen Sun, Guoyu Duan
exaly +3 more sources
European Journal of Inflammation, 2021 Introduction Macrophages are capable of exerting both proinflammatory and anti-inflammatory functions in response to distinct environmental stimuli, by polarizing into classically inflammatory state (M1) and anti-inflammatory phenotype (M2), respectively.
Jiali Yang +9 more
doaj +1 more source
Recruitment and training of alveolar macrophages after pneumococcal pneumonia
JCI Insight, 2022 Recovery from pneumococcal pneumonia remodels the pool of alveolar macrophages so that they exhibit new surface marker profiles, transcriptomes, metabolomes, and responses to infection.
Emad I. Arafa +16 more
doaj +1 more source
JCI Insight, 2022 Tissue-resident macrophage-based immune therapies have been proposed for various diseases. However, generation of sufficient numbers that possess tissue-specific functions remains a major handicap. Here, we showed that fetal liver monocytes cultured with
Fengqi Li +5 more
doaj +1 more source
The alveolar macrophage. [PDF]
Environmental Health Perspectives, 1971 The pulmonary macrophagic system is critical to the defense of the lung, keeping the alveoli clean and sterile and responding on demand with an adaptive outpouring of new cells into the air sacs. Under basal conditions alveolar macrophages, in common with other mononuclear phagocytes, are derived from the bone marrow.
openaire +3 more sources
Acute Penicillium marneffei infection stimulates host M1/M2a macrophages polarization in BALB/C mice
BMC Microbiology, 2017 Background Penicillium marneffei (P. marneffei) is a thermally dimorphic fungus pathogen that causes fatal infection. Alveolar macrophages are innate immune cells that have critical roles in protection against pulmonary fungal pathogens and the ...
Xiaoying Dai +13 more
doaj +1 more source
BMC Immunology, 2012 Background Alveolar macrophages are one of the first lines of defence against invading pathogens and play a central role in modulating both the innate and acquired immune systems.
Groot-Kormelink Paul J +4 more
doaj +1 more source