Results 21 to 30 of about 331,012 (291)
Haematologica, 2020 Hereditary pulmonary alveolar proteinosis due to GM-CSF receptor deficiency (herPAP) constitutes a life-threatening lung disease characterized by alveolar deposition of surfactant protein secondary to defective alveolar macrophage function.
Miriam Hetzel +16 more
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Alveolar Macrophage in the Driver's Seat [PDF]
Immunity, 2006 Although alveolar macrophages are normally quiescent to prevent damaging the alveoli, in this issue of Immunity, Takabayshi et al. (2006) demonstrate that alveolar macrophages can self-regulate their function on demand to mount an appropriate immune response.
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Bronchoalveolar lavage (BAL) cells in idiopathic pulmonary fibrosis express a complex pro-inflammatory, pro-repair, angiogenic activation pattern, likely associated with macrophage iron accumulation. [PDF]
PLoS ONE, 2018 Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of unknown cause characterized by alveolar epithelial damage, patchy interstitial fibrosis and diffuse microvascular abnormalities.
Jungnam Lee +9 more
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Development and Functions of Alveolar Macrophages
Molecules and Cells, 2021 Macrophages residing in various tissue types are unique in terms of their anatomical locations, ontogenies, developmental pathways, gene expression patterns, and immunological functions. Alveolar macrophages (AMs) reside in the alveolar lumen of the lungs and serve as the first line of defense for the respiratory tract.
Yeon Duk Woo +2 more
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Characterisation of lung macrophage subpopulations in COPD patients and controls
Scientific Reports, 2017 Lung macrophage subpopulations have been identified based on size. We investigated characteristics of small and large macrophages in the alveolar spaces and lung interstitium of COPD patients and controls.
Jennifer A. Dewhurst +5 more
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Alveolar hypoxia, alveolar macrophages, and systemic inflammation [PDF]
Respiratory Research, 2009 Abstract Diseases featuring abnormally low alveolar PO2 are frequently accompanied by systemic effects. The common presence of an underlying inflammatory component suggests that inflammation may contribute to the pathogenesis of the systemic effects of alveolar hypoxia.
Gonzalez Norberto C +2 more
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Acta Pharmaceutica Sinica B, 2022 Severe acute pancreatitis-associated acute lung injury (SAP-ALI) is a serious disease associated with high mortality. Emodin has been applied to alleviate SAP-ALI; however, the mechanism remains unclear.
Qian Hu +7 more
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Phagolysosomal pH in Alveolar Macrophages [PDF]
Environmental Health Perspectives, 1992 We studied phagolysosomal pH in alveolar macrophages (AM) using fluorescein-labeled yeast (FYP) and silica particles (FSP) as probes. Fluorescence intensities from the ingested test particles were measured on populations of AM using fluorescence spectrometry and on individual phagolysosomes using fluorescence microscopy.
K, Nyberg +3 more
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iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice
Stem Cell Reports, 2018 Summary: Induced pluripotent stem cell (iPSC)-derived hematopoietic cells represent a highly attractive source for cell and gene therapy. Given the longevity, plasticity, and self-renewal potential of distinct macrophage subpopulations, iPSC-derived ...
Adele Mucci +22 more
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Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury
Respiratory Research, 2005 Background Alveolar macrophages play an important role during the development of acute inflammatory lung injury. In the present study, in vivo alveolar macrophage depletion was performed by intratracheal application of dichloromethylene diphosphonate ...
Reyes Livia +5 more
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