Alveolar hypoxia, alveolar macrophages, and systemic inflammation [PDF]
Respiratory Research, 2009 Diseases featuring abnormally low alveolar PO2 are frequently accompanied by systemic effects. The common presence of an underlying inflammatory component suggests that inflammation may contribute to the pathogenesis of the systemic effects of alveolar ...
Gonzalez Norberto C +2 more
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Quantitative GPCR and ion channel transcriptomics in primary alveolar macrophages and macrophage surrogates [PDF]
BMC Immunology, 2012 Background Alveolar macrophages are one of the first lines of defence against invading pathogens and play a central role in modulating both the innate and acquired immune systems.
Groot-Kormelink Paul J +4 more
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Toxins, 2023 Aflatoxin B1 (AFB1), one of the most common environmental mycotoxin contaminations in food and feed, poses significant threats to human and animal health.
Yuhang Sun +5 more
doaj +1 more source
Explaining the polarized macrophage pool during murine allergic lung inflammation
Frontiers in Immunology, 2022 IntroductionDifferentially polarized macrophages, especially YM1+ and MHCII+ macrophages, play an important role in asthma development. The origin of these polarized macrophages has not been elucidated yet.
Christina Draijer +9 more
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Comparison between sevoflurane and propofol on immunomodulation in an in vitro model of sepsis
Frontiers in Medicine, 2023 IntroductionPatients with sepsis often require sedation and/or anesthesia. Although the immunomodulatory effects of anesthetics have been increasingly recognized, the molecular mechanisms require better elucidation. We compared the effects of sevoflurane
Tainá B. Oliveira +7 more
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Cell Reports, 2020 Summary: Acute lung injury (ALI) is a lethal inflammatory lung disorder whose incidence is on the rise. Alveolar macrophages normally act to resolve inflammation, but when dysregulated they can provoke ALI.
Jagdish C. Joshi +11 more
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Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease. [PDF]
PLoS ONE, 2014 We have previously reported that the lungs of patients with very severe chronic obstructive pulmonary disease (COPD) contain significantly higher numbers of alveolar macrophages than those of non-smokers or smokers.
Yoichiro Kaku +10 more
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Case report: Mafb promoter activity may define the alveolar macrophage dichotomy
Frontiers in Immunology, 2022 Cre-LoxP system has been widely used to induce recombination of floxed genes of interest. Currently available macrophage promoter-specific Cre recombinase mice strains have various limitations that warrants the testing of additional Cre strains.
Thao Vo, Yogesh Saini
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Differential response of primary alveolar type I and type II cells to LPS stimulation. [PDF]
, 2013 The alveolar epithelium serves as a barrier between organism and environment and functions as the first line of protection against potential respiratory pathogens.
Johnson, Meshell D, Wong, Mandi H
core +7 more sources
Recruitment and training of alveolar macrophages after pneumococcal pneumonia
JCI Insight, 2022 Recovery from pneumococcal pneumonia remodels the pool of alveolar macrophages so that they exhibit new surface marker profiles, transcriptomes, metabolomes, and responses to infection.
Emad I. Arafa +16 more
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