Results 1 to 10 of about 114,838 (266)

Alveolar Macrophages Participate in the Promotion of Influenza Virus Infection by Aflatoxin B1 at an Early Stage

Toxins, 2023
Aflatoxin B1 (AFB1), one of the most common environmental mycotoxin contaminations in food and feed, poses significant threats to human and animal health.
Yuhang Sun, Zhaoran Yao, Miao Long, Ying Zhang, Kehe Huang, Lin Li   +5 more
doaj   +1 more source

Explaining the polarized macrophage pool during murine allergic lung inflammation

Frontiers in Immunology, 2022
IntroductionDifferentially polarized macrophages, especially YM1+ and MHCII+ macrophages, play an important role in asthma development. The origin of these polarized macrophages has not been elucidated yet.
Christina Draijer, Laura Florez-Sampedro, Laura Florez-Sampedro, Laura Florez-Sampedro, Catharina Reker-Smit, Eduard Post, Fransien van Dijk, Fransien van Dijk, Barbro N. Melgert, Barbro N. Melgert   +9 more
doaj   +1 more source

SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages

Cell Reports, 2020
Summary: Acute lung injury (ALI) is a lethal inflammatory lung disorder whose incidence is on the rise. Alveolar macrophages normally act to resolve inflammation, but when dysregulated they can provoke ALI.
Jagdish C. Joshi, Bhagwati Joshi, Ian Rochford, Sheikh Rayees, Md Zahid Akhter, Sukriti Baweja, Koteshwara Rao Chava, Mohammad Tauseef, Hazem Abdelkarim, Viswanathan Natarajan, Vadim Gaponenko, Dolly Mehta   +11 more
doaj   +1 more source

Comparison between sevoflurane and propofol on immunomodulation in an in vitro model of sepsis

Frontiers in Medicine, 2023
IntroductionPatients with sepsis often require sedation and/or anesthesia. Although the immunomodulatory effects of anesthetics have been increasingly recognized, the molecular mechanisms require better elucidation. We compared the effects of sevoflurane
Tainá B. Oliveira, Cassia L. Braga, Denise Battaglini, Paolo Pelosi, Paolo Pelosi, Patricia R. M. Rocco, Pedro L. Silva, Fernanda F. Cruz   +7 more
doaj   +1 more source

Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease. [PDF]

PLoS ONE, 2014
We have previously reported that the lungs of patients with very severe chronic obstructive pulmonary disease (COPD) contain significantly higher numbers of alveolar macrophages than those of non-smokers or smokers.
Yoichiro Kaku, Haruki Imaoka, Yoshitaka Morimatsu, Yoshihiro Komohara, Koji Ohnishi, Hanako Oda, Shinichi Takenaka, Masanobu Matsuoka, Tomotaka Kawayama, Motohiro Takeya, Tomoaki Hoshino   +10 more
doaj   +1 more source

Case report: Mafb promoter activity may define the alveolar macrophage dichotomy

Frontiers in Immunology, 2022
Cre-LoxP system has been widely used to induce recombination of floxed genes of interest. Currently available macrophage promoter-specific Cre recombinase mice strains have various limitations that warrants the testing of additional Cre strains.
Thao Vo, Yogesh Saini
doaj   +1 more source

Recruitment and training of alveolar macrophages after pneumococcal pneumonia

JCI Insight, 2022
Recovery from pneumococcal pneumonia remodels the pool of alveolar macrophages so that they exhibit new surface marker profiles, transcriptomes, metabolomes, and responses to infection.
Emad I. Arafa, Anukul T. Shenoy, Kimberly A. Barker, Neelou S. Etesami, Ian M.C. Martin, Carolina Lyon De Ana, Elim Na, Christine V. Odom, Wesley N. Goltry, Filiz T. Korkmaz, Alicia K. Wooten, Anna C. Belkina, Antoine Guillon, E. Camilla Forsberg, Matthew R. Jones, Lee J. Quinton, Joseph P. Mizgerd   +16 more
doaj   +1 more source

Decreased expression of a phagocytic receptor Siglec-1 on alveolar macrophages in chronic obstructive pulmonary disease

Respiratory Research, 2020
Background Alveolar macrophages are professional phagocytes that remove microbial pathogens inhaled into the lung. The phagocytic ability is compromised in chronic obstructive pulmonary disease (COPD).
Atsushi Tanno, Naoya Fujino, Mitsuhiro Yamada, Hisatoshi Sugiura, Taizou Hirano, Rie Tanaka, Hirohito Sano, Satoshi Suzuki, Yoshinori Okada, Masakazu Ichinose   +9 more
doaj   +1 more source

Paraquat promotes acute lung injury in rats by regulating alveolar macrophage polarization through glycolysis

Ecotoxicology and Environmental Safety, 2021
The present study investigates whether paraquat (PQ) regulates polarization of alveolar macrophages through glycolysis and promotes the occurrence of acute lung injury in rats.
Yan Zhang, Ding Yuan, Yi Li, Fang Yang, Linlin Hou, Yanwu Yu, Changhua Sun, Guoyu Duan, Cuicui Meng, Hongyi Yan, Dongxu Li, Yanxia Gao, Tongwen Sun, Changju Zhu   +13 more
doaj   +1 more source

Alveolar macrophages lack CCR2 expression and do not migrate to CCL2

Journal of Inflammation, 2007
Background The recruitment of mononuclear cells has important implications for tissue inflammation. Previous studies demonstrated enhanced CCR1 and CCR5 expression and decreased CCR2 expression during in vitro monocyte to macrophage differentiation.
Hunter Melissa G, Lobb Jennifer M, Ali Naeem A, Opalek Judy M, Marsh Clay B   +4 more
doaj   +1 more source