Results 11 to 20 of about 183,665 (310)
Respiratory Research, 2020 Background Alveolar macrophages are professional phagocytes that remove microbial pathogens inhaled into the lung. The phagocytic ability is compromised in chronic obstructive pulmonary disease (COPD).
Atsushi Tanno +9 more
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Alveolar macrophages and the diagnosis of drowning [PDF]
, 1993 In the present study, we examined the number of alveolar macrophages in lung tissue from 17 cases of fresh water drowning, 22 cases of acute death and 6 cases of lung emphysema.
A. Nerlich +12 more
core +1 more source
Pulmonary giant cells and their significance for the diagnosis of asphyxiation [PDF]
, 1993 This study was performed to prove whether the detection of polynuclear giant cells in lungs is useful for the diagnosis of asphyxiation due to throttling or strangulation.
A. Nerlich +12 more
core +1 more source
The alveolar macrophage. [PDF]
Environmental Health Perspectives, 1971 The pulmonary macrophagic system is critical to the defense of the lung, keeping the alveoli clean and sterile and responding on demand with an adaptive outpouring of new cells into the air sacs. Under basal conditions alveolar macrophages, in common with other mononuclear phagocytes, are derived from the bone marrow.
openaire +3 more sources
Ecotoxicology and Environmental Safety, 2021 The present study investigates whether paraquat (PQ) regulates polarization of alveolar macrophages through glycolysis and promotes the occurrence of acute lung injury in rats.
Yan Zhang +13 more
doaj +1 more source
Alveolar macrophages lack CCR2 expression and do not migrate to CCL2
Journal of Inflammation, 2007 Background The recruitment of mononuclear cells has important implications for tissue inflammation. Previous studies demonstrated enhanced CCR1 and CCR5 expression and decreased CCR2 expression during in vitro monocyte to macrophage differentiation.
Hunter Melissa G +4 more
doaj +1 more source
Characterisation of lung macrophage subpopulations in COPD patients and controls
Scientific Reports, 2017 Lung macrophage subpopulations have been identified based on size. We investigated characteristics of small and large macrophages in the alveolar spaces and lung interstitium of COPD patients and controls.
Jennifer A. Dewhurst +5 more
doaj +1 more source
Disparate oxidant gene expression of airway epithelium compared to alveolar macrophages in smokers
Respiratory Research, 2009 Background The small airway epithelium and alveolar macrophages are exposed to oxidants in cigarette smoke leading to epithelial dysfunction and macrophage activation. In this context, we asked: what is the transcriptome of oxidant-related genes in small
Hackett Neil R +5 more
doaj +1 more source
IL-1R and inflammasomes mediate early pulmonary protective mechanisms in respiratory brucella abortus infection [PDF]
, 2016 Brucella spp. infection is frequently acquired through contaminated aerosols. The role of interleukin-1 beta (IL-1β) in the early pulmonary response to respiratory Brucella infection is unknown.
Alonso Paiva, Iván Mathias +9 more
core +1 more source
Cigarette smoking decreases global microRNA expression in human alveolar macrophages. [PDF]
PLoS ONE, 2012 Human alveolar macrophages are critical components of the innate immune system. Cigarette smoking-induced changes in alveolar macrophage gene expression are linked to reduced resistance to pulmonary infections and to the development of emphysema/COPD. We
Joel W Graff +9 more
doaj +1 more source