Results 11 to 20 of about 114,838 (266)
Alveolar hypoxia, alveolar macrophages, and systemic inflammation [PDF]
Respiratory Research, 2009 Diseases featuring abnormally low alveolar PO2 are frequently accompanied by systemic effects. The common presence of an underlying inflammatory component suggests that inflammation may contribute to the pathogenesis of the systemic effects of alveolar ...
Gonzalez Norberto C +2 more
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The alveolar macrophage. [PDF]
Environmental Health Perspectives, 1971 The pulmonary macrophagic system is critical to the defense of the lung, keeping the alveoli clean and sterile and responding on demand with an adaptive outpouring of new cells into the air sacs. Under basal conditions alveolar macrophages, in common with other mononuclear phagocytes, are derived from the bone marrow.
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Cigarette smoking decreases global microRNA expression in human alveolar macrophages. [PDF]
PLoS ONE, 2012 Human alveolar macrophages are critical components of the innate immune system. Cigarette smoking-induced changes in alveolar macrophage gene expression are linked to reduced resistance to pulmonary infections and to the development of emphysema/COPD. We
Joel W Graff +9 more
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Characterisation of lung macrophage subpopulations in COPD patients and controls
Scientific Reports, 2017 Lung macrophage subpopulations have been identified based on size. We investigated characteristics of small and large macrophages in the alveolar spaces and lung interstitium of COPD patients and controls.
Jennifer A. Dewhurst +5 more
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Disparate oxidant gene expression of airway epithelium compared to alveolar macrophages in smokers
Respiratory Research, 2009 Background The small airway epithelium and alveolar macrophages are exposed to oxidants in cigarette smoke leading to epithelial dysfunction and macrophage activation. In this context, we asked: what is the transcriptome of oxidant-related genes in small
Hackett Neil R +5 more
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Vestnik MGTU, 2022 The goal of studying the mechanisms of action of cells that structure the immune system is to obtain additional data about the influence of immunomodulating peptides of natural origin on the possibility of regulating immune processes.
Kolberg N. A. +3 more
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Alveolar Macrophage in the Driver's Seat [PDF]
Immunity, 2006 Although alveolar macrophages are normally quiescent to prevent damaging the alveoli, in this issue of Immunity, Takabayshi et al. (2006) demonstrate that alveolar macrophages can self-regulate their function on demand to mount an appropriate immune response.
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Lung collagens perpetuate pulmonary fibrosis via CD204 and M2 macrophage activation. [PDF]
PLoS ONE, 2013 Idiopathic pulmonary fibrosis is characterized by abundant collagen production and accumulation of alternatively activated macrophages (M2) in the lower respiratory tract.
Mirjam Stahl +6 more
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Development and Functions of Alveolar Macrophages
Molecules and Cells, 2021 Macrophages residing in various tissue types are unique in terms of their anatomical locations, ontogenies, developmental pathways, gene expression patterns, and immunological functions. Alveolar macrophages (AMs) reside in the alveolar lumen of the lungs and serve as the first line of defense for the respiratory tract.
Yeon Duk Woo +2 more
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Diversity of Macrophages in Lung Homeostasis and Diseases
Frontiers in Immunology, 2021 Lung macrophages play important roles in the maintenance of homeostasis, pathogen clearance and immune regulation. The different types of pulmonary macrophages and their roles in lung diseases have attracted attention in recent years.
Fei Hou +4 more
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