Results 1 to 10 of about 1,184,873 (292)
Cell Reports, 2020 Summary: Acute lung injury (ALI) is a lethal inflammatory lung disorder whose incidence is on the rise. Alveolar macrophages normally act to resolve inflammation, but when dysregulated they can provoke ALI.
Md Zahid Akhter +2 more
exaly +4 more sources
Senescent alveolar macrophages promote early-stage lung tumorigenesis
Cancer Cell, 2023 Summary Senescent cells play relevant but context-dependent roles during tumorigenesis. Here, in an oncogenic Kras-driven lung cancer mouse model, we found that senescent cells, specifically alveolar macrophages, accumulate early in neoplasia.
Darren J Baker +2 more
exaly +2 more sources
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth
Journal of Experimental Medicine, 2021 This study identifies AT2s as the relevant source of GM-CSF for the development and maintenance of alveolar macrophages. During organogenesis, nascent AT2s induce GM-CSF expression in a perfectly timed manner to support the proliferation and ...
Julia Gschwend +2 more
exaly +2 more sources
Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis
Cell, 2020 During respiration, humans breathe in more than 10,000 liters of non-sterile air daily, allowing some pathogens access to alveoli. Interestingly, alveoli outnumber alveolar macrophages (AMs), which favors alveoli devoid of AMs.
Moritz Peiseler +2 more
exaly +2 more sources
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
Journal of Experimental Medicine, 2017 Little is known about the relative importance of monocyte and tissue-resident macrophages in the development of lung fibrosis. We show that specific genetic deletion of monocyte-derived alveolar macrophages after their recruitment to the lung ameliorated
Sergejs Berdnikovs +2 more
exaly +2 more sources
Cell, 2018 Innate immune memory is an emerging area of research. However, innate immune memory at major mucosal sites remains poorly understood. Here, we show that respiratory viral infection induces long-lasting memory alveolar macrophages (AMs).
Yushi Yao, Anna Dvorkin-Gheva, Zhou Xing
exaly +2 more sources
Cholesterol-mediated inflammation activation in alveolar macrophages [PDF]
BMC BiologyBackground The role of cholesterol- and cholesterol crystal-mediated inflammation has been extensively investigated in circulating macrophages in the context of cardiovascular diseases while little is known about its contribution to lung diseases ...
Sonia Giambelluca +2 more
doaj +2 more sources
Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination
Cell Host and Microbe, 2018 Mycobacterium tuberculosis (Mtb) infection is initiated in the distal airways, but the bacteria ultimately disseminate to the lung interstitium. Although various cell types, including alveolar macrophages (AM), neutrophils, and permissive monocytes, are ...
Michael Y Gerner +2 more
exaly +2 more sources
Cellular Immunology, 2018 Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation ...
James M. Walter +2 more
exaly +2 more sources
Cell Host and Microbe, 2020 Summary Alveolar macrophages are among the first immune cells that respond to inhaled pathogens. However, numerous pathogens block macrophage-intrinsic immune responses, making it unclear how robust antimicrobial responses are generated.
Sunny Shin +2 more
exaly +2 more sources