Results 11 to 20 of about 1,184,873 (292)

Alveolar hypoxia, alveolar macrophages, and systemic inflammation [PDF]

Respiratory Research, 2009
Diseases featuring abnormally low alveolar PO2 are frequently accompanied by systemic effects. The common presence of an underlying inflammatory component suggests that inflammation may contribute to the pathogenesis of the systemic effects of alveolar ...
Gonzalez Norberto C, Wood John G, Chao Jie   +2 more
doaj   +3 more sources

Recruitment and training of alveolar macrophages after pneumococcal pneumonia [PDF]

JCI Insight, 2022
Recovery from pneumococcal pneumonia remodels the pool of alveolar macrophages so that they exhibit new surface marker profiles, transcriptomes, metabolomes, and responses to infection.
Emad I. Arafa, Anukul T. Shenoy, Kimberly A. Barker, Neelou S. Etesami, Ian M.C. Martin, Carolina Lyon De Ana, Elim Na, Christine V. Odom, Wesley N. Goltry, Filiz T. Korkmaz, Alicia K. Wooten, Anna C. Belkina, Antoine Guillon, E. Camilla Forsberg, Matthew R. Jones, Lee J. Quinton, Joseph P. Mizgerd   +16 more
doaj   +2 more sources

Cigarette smoking decreases global microRNA expression in human alveolar macrophages. [PDF]

PLoS ONE, 2012
Human alveolar macrophages are critical components of the innate immune system. Cigarette smoking-induced changes in alveolar macrophage gene expression are linked to reduced resistance to pulmonary infections and to the development of emphysema/COPD. We
Joel W Graff, Linda S Powers, Anne M Dickson, Jongkwang Kim, Anna C Reisetter, Ihab H Hassan, Karol Kremens, Thomas J Gross, Mary E Wilson, Martha M Monick   +9 more
doaj   +2 more sources

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

Journal of Experimental Medicine, 2013
Alveolar macrophages differentiate from fetal monocytes in a GM-CSF–dependent fashion and colonize the alveolar space within a few days after birth.
Sandrine Henri, Bernard Malissen, Martin Guilliams   +2 more
exaly   +2 more sources

The deadly dance of alveolar macrophages and influenza virus

European Respiratory Review
Influenza A virus (IAV) is one of the leading causes of respiratory infections. The lack of efficient anti-influenza therapeutics requires a better understanding of how IAV interacts with host cells.
Camille David, Charles Verney, Mustapha Si-Tahar, Antoine Guillon   +3 more
doaj   +2 more sources

Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury [PDF]

Respiratory Research, 2005
Background Alveolar macrophages play an important role during the development of acute inflammatory lung injury. In the present study, in vivo alveolar macrophage depletion was performed by intratracheal application of dichloromethylene diphosphonate ...
Reyes Livia, Pasch Thomas, Schwendener Reto, Beck-Schimmer Beatrice, Booy Christa, Schimmer Ralph C   +5 more
doaj   +3 more sources

Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages

Cell Death and Differentiation, 2016
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes involved in shaping adaptive immune responses, but their role in innate immune ...
Shanze Chen, I. Kammerl, Oliver Vosyka, Tobias Baumann, Y. Yu, Yiquan Wu, M. Irmler, H. Overkleeft, J. Beckers, O. Eickelberg, S. Meiners, T. Stoeger   +11 more
semanticscholar   +2 more sources

Alveolar Macrophages Participate in the Promotion of Influenza Virus Infection by Aflatoxin B1 at an Early Stage

Toxins, 2023
Aflatoxin B1 (AFB1), one of the most common environmental mycotoxin contaminations in food and feed, poses significant threats to human and animal health.
Yuhang Sun, Zhaoran Yao, Miao Long, Ying Zhang, Kehe Huang, Lin Li   +5 more
doaj   +1 more source

Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting

Journal of Clinical Investigation, 2023
Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining homeostasis, fending off pathogens, and controlling lung inflammation.
C. Malainou, S. Abdin, N. Lachmann, U. Matt, S. Herold   +4 more
semanticscholar   +1 more source

AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages

Theranostics, 2022
Rationale: Aberrant activation of macrophages with mitochondria dismiss was proved to be associated with pathogenesis of ALI (acute lung injury). Exosomes from adipose-derived mesenchymal stem cells (AdMSC-Exos) have been distinguished by their low ...
Liang-Jun Xia, Chun-Li Zhang, Nianyin Lv, Zi-Hao Liang, Tonghui Ma, Hai-Bo Cheng, Youbing Xia, Liyun Shi   +7 more
semanticscholar   +1 more source