Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease
Thorax, 2021 Cigarette smoking is the leading cause of preventable death worldwide. It causes chronic lung disease and predisposes individuals to acute lung injury and pulmonary infection.
S. Lugg +4 more
semanticscholar +1 more source
Explaining the polarized macrophage pool during murine allergic lung inflammation
Frontiers in Immunology, 2022 IntroductionDifferentially polarized macrophages, especially YM1+ and MHCII+ macrophages, play an important role in asthma development. The origin of these polarized macrophages has not been elucidated yet.
Christina Draijer +9 more
doaj +1 more source
Journal of Experimental Medicine, 2023 Chakraborty et al. demonstrate that a subset of tissue-resident alveolar macrophages shows greater capacity for efferocytosis and prevents hyperinflammation following repeated pathogen challenges.
Sreeparna Chakraborty +10 more
semanticscholar +1 more source
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging.
Journal of Clinical Investigation, 2021 Alveolar macrophages orchestrate the response to viral infections. Age-related changes in these cells may underlie the differential severity of pneumonia in older patients.
Alexandra C. McQuattie-Pimentel +33 more
semanticscholar +1 more source
Comparison between sevoflurane and propofol on immunomodulation in an in vitro model of sepsis
Frontiers in Medicine, 2023 IntroductionPatients with sepsis often require sedation and/or anesthesia. Although the immunomodulatory effects of anesthetics have been increasingly recognized, the molecular mechanisms require better elucidation. We compared the effects of sevoflurane
Tainá B. Oliveira +7 more
doaj +1 more source
Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease. [PDF]
PLoS ONE, 2014 We have previously reported that the lungs of patients with very severe chronic obstructive pulmonary disease (COPD) contain significantly higher numbers of alveolar macrophages than those of non-smokers or smokers.
Yoichiro Kaku +10 more
doaj +1 more source
Development and Functions of Alveolar Macrophages
Molecules and Cells, 2021 Macrophages residing in various tissue types are unique in terms of their anatomical locations, ontogenies, developmental pathways, gene expression patterns, and immunological functions.
Y. Woo, Dongjin Jeong, D. Chung
semanticscholar +1 more source
Case report: Mafb promoter activity may define the alveolar macrophage dichotomy
Frontiers in Immunology, 2022 Cre-LoxP system has been widely used to induce recombination of floxed genes of interest. Currently available macrophage promoter-specific Cre recombinase mice strains have various limitations that warrants the testing of additional Cre strains.
Thao Vo, Yogesh Saini
doaj +1 more source
bioRxiv, 2021 Alveolar macrophages are the most abundant macrophages in the healthy lung where they play key roles in homeostasis and immune surveillance against air-borne pathogens.
Jack McCowan +20 more
semanticscholar +1 more source
Antioxidant Efficacy of Flavonoid in Broccoli (Brassica oleracea var. italica) to Decrease Alveolar Macrophages in Lung Tissue Due to Cigarette Smoke Exposure [PDF]
, 2022 Cigarette smoke has shown various kinds of free radical content. The increasing number of free radicals from exposure to cigarette smoke that enters the respiratory tract may result in lung tissue damage.
Wicaksono, Adhimas Setyo +3 more
core +2 more sources