Results 151 to 160 of about 368,637 (232)

Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective Although dopamine transporter (DaT) imaging is a valuable diagnostic biomarker, few studies have investigated its utility in objectively monitoring disease progression in patients with Parkinson's disease (PD). To date, no study has established a longitudinal relationship between the DaT signal decline and the motor symptom increase ...
Verena Dzialas, Gérard N. Bischof, Kathrin Möllenhoff, Alexander Drzezga, Thilo van Eimeren   +4 more
wiley   +1 more source

Alzheimer's disease and insomnia: a bibliometric study and visualization analysis. [PDF]

Front Aging Neurosci
Tian ZY, Jiang B, Jin M, Yu XK, Chen QL, Wang JH.   +5 more
europepmc   +1 more source

AI in Neurology: Everything, Everywhere, all at Once PART 2: Speech, Sentience, Scruples, and Service

Annals of Neurology, EarlyView.
Artificial intelligence (AI) applications are finding use in real‐world neurological settings. Whereas part 1 of this 3‐part review series focused on the birth of AI and its foundational principles, this part 2 review shifts gears to explore more practical aspects of neurological care.
Matthew Rizzo
wiley   +1 more source

Sex differences in story recall decline in preclinical Alzheimer's disease. [PDF]

Brain Commun
Cowman D, Langhough R, Olson H, Basche K, Sanson-Miles L, Bruno D, Hermann B, Christian BT, Betthauser TJ, Johnson SC, Mueller KD.   +10 more
europepmc   +1 more source

AI in Neurology: Everything, Everywhere, All at Once Part 3: Surveillance, Synthesis, Simulation, and Systems

Annals of Neurology, EarlyView.
This final part 3 review builds on the practical applications discussed in part 2 and explores how artificial intelligence (AI) is transforming data management, neurological education, and neurological care across large healthcare networks and datasets. The review also highlights AI's role in real‐world and synthetic data, digital twins, and innovative
Matthew Rizzo
wiley   +1 more source

Intrinsically Disordered Peptide Nanofibers from a Structured Motif Within Proteins

Angewandte Chemie, EarlyView.
The sequence (PQYQP), derived from the SRC protein, was combined with the self‐assembly motif (Nap‐FF) to produce intrinsically disordered peptide (IDP) assemblies that form cell‐compatible hydrogels via enzyme‐instructed self‐assembly (EISA). Abstract Intrinsically disordered regions (IDRs) are ubiquitous in proteins, orchestrating complex cellular ...
Yuchen Qiao, Ayisha Zia, Adrianna Shy, Grace Wu, Matthew Chu, Zhiyu Liu, Fengbin Wang, Bing Xu   +7 more
wiley   +2 more sources

Longitudinal Analysis of Neuroradiological Biomarkers for Fragile X‐Associated Tremor/Ataxia Syndrome and Implications for Clinical Trials

Annals of Neurology, EarlyView.
Objective The objective of this study was to show the capacity of structural brain magnetic resonance imaging (MRI) measures to serve as monitoring biomarkers for Fragile X‐Associated Tremor/Ataxia Syndrome (FXTAS). Methods From 2 longitudinal studies of male FMR1 premutation carriers, 2 brain MRI scans were selected from each participant, collected ...
David Hessl, Jun Yi Wang, Glenda Espinal, Ellery Santos, Flora Tassone, Randi J. Hagerman, Susan M. Rivera   +6 more
wiley   +1 more source

A Single‐Molecule Liposome Assay for Membrane Permeabilization

Angewandte Chemie, EarlyView.
The rapid screening of compounds capable of disrupting or permeabilizing biological membranes is essential to the search for new therapeutics. Here, we present an ultrasensitive single‐molecule confocal microscopy assay combined with fast‐flow microfluidics to study membrane permeabilization in large unilamellar vesicles (LUVs).
Krzysztof M. Bąk, Daniel C. Edwards, Dylan George, Bhanu Singh, Ryan Ferguson, Tianxiao Zhao, Kristin Piché, Ariel Louwrier, Scott L. Cockroft, Mathew H. Horrocks   +9 more
wiley   +2 more sources

Astrocyte and oligodendrocyte pathology in Alzheimer's disease. [PDF]

Neurotherapeutics
Ziar R, Tesar PJ, Clayton BLL.
europepmc   +1 more source