Results 161 to 170 of about 340,510 (279)

Epidemiology of Alzheimer's disease : occurrence, determinants, and strategies toward intervention

, 2009
More than 25 million people in the world today are affected by dementia, most suffering from Alzheimer's disease. In both developed and developing nations, Alzheimer's disease has had tremendous impact on the affected individuals, caregivers, and society.
Qiu, C, Kivipelto, M, von Strauss, Eva,
core  

Associations of circulating resistin with Alzheimer's disease biomarkers and cognitive function in the preclinical stage of Alzheimer's disease. [PDF]

J Alzheimers Dis
Eruysal E, Ravdin L, Iadecola C, Ishii M.   +3 more
europepmc   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Stress, stress systems, and Alzheimer's disease. [PDF]

Alzheimers Dement
Eberly SG, Phumsatitpong C, Munro CE, Neylan TC, Kaufer D, Ehrenberg AJ.   +5 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Alzheimer's disease polygenic risk in early- and late-onset Alzheimer's disease. [PDF]

Alzheimers Dement
Pentchev JV, Jackson T, Khan N, Rosewood TJ, Huang YN, Nho K, Saykin AJ, Eloyan A, Taurone A, Thangarajah M, Riddle M, Salloway S, Atri A, Honig LS, Johnson ECB, Turner RS, Masdeu JC, Foroud TM, Clark D, Hammers DB, Dage JL, Kirby K, Ghetti B, Newell K, Onyike CU, Day GS, Graff-Radford NR, Murray ME, Jones DT, Jack CR, Vemuri P, Touroutoglou A, Duara R, Grant I, Sha S, Wingo TS, Beckett LA, Rogalski E, Mendez MF, Kramer J, La Joie R, Blazhenets G, Grinberg LT, Koeppe R, Wolk DA, Aisen P, Raman R, Toga A, Kukull WA, Musiek E, Womack KB, Carrillo MC, Rabinovici GD, Dickerson BC, Apostolova LG, Nudelman KNH, Longitudinal Early‐Onset Alzheimer's Disease Study Consortium and the Alzheimer's Disease Neuroimaging Initiative.   +56 more
europepmc   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Current understanding of AD pathophysiology and impact of amyloid‐beta targeted treatments on biomarkers and clinical endpoints

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Ronald C. Petersen, Ana Graf, Maria C. Carrillo, Christopher J. Weber   +3 more
doaj   +1 more source

Digital speech-based markers to advance prognosis in Alzheimer's disease. [PDF]

Alzheimers Dement
Lee M, Meylan S, Shobin E, SpeechDx Consortium, Nisenbaum L, Sukumar A, Kourtis L.   +6 more
europepmc   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source