Results 181 to 190 of about 9,372,438 (357)

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

Challenges and Opportunities of Clinicopathological Investigation in Longitudinal Studies of Alzheimer's Disease [PDF]

, 1986
Melvyn J. Ball
openalex   +1 more source

Alzheimer's Disease [PDF]

Annual Review of Public Health, 1989
B T, Hyman, H, Damasio, A R, Damasio, G W, Van Hoesen   +3 more
openaire   +2 more sources

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Diabetes and Alzheimer's Disease. [PDF]

J Diabetes
Bloomgarden Z.
europepmc   +1 more source

Neuropsychological Symptoms in Cases Suspected of Alzheimer's Disease

, 1986
Matsubara Saburo, Wataru Nakayama, Eisaku Mihara, Akira Tamai, Hideaki Enokido   +4 more
openalex   +2 more sources

Alzheimer's Disease [PDF]

, 1980
M. Swash
openalex   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Disease stage-specific atrophy markers in Alzheimer's disease. [PDF]

Alzheimers Dement
Baumeister H, Gellersen HM, Polk SE, Lattmann R, Wuestefeld A, Wisse LEM, Glenn T, Yakupov R, Stark M, Kleineidam L, Roeske S, Morgado BM, Esselmann H, Brosseron F, Ramirez A, Lüsebrink F, Synofzik M, Schott BH, Schmid MC, Hetzer S, Dechent P, Scheffler K, Ewers M, Hellmann-Regen J, Ersözlü E, Spruth E, Gemenetzi M, Fliessbach K, Bartels C, Rostamzadeh A, Glanz W, Incesoy EI, Janowitz D, Rauchmann BS, Kilimann I, Sodenkamp S, Coenjaerts M, Spottke A, Peters O, Priller J, Schneider A, Wiltfang J, Buerger K, Perneczky R, Teipel S, Laske C, Wagner M, Ziegler G, Jessen F, Düzel E, Berron D, DELCODE study group.   +51 more
europepmc   +1 more source

Alzheimer's disease and senile dementia of Alzheimer type

, 1982
Raimo Sulkava
openalex   +1 more source