Results 181 to 190 of about 9,230,509 (381)

A retrospective analysis of serious adverse events and deaths in U.S.-based lifestyle clinical trials for cognitive health

Contemporary Clinical Trials Communications
Objective: This retrospective analysis examined serious adverse events (SAEs) and deaths in U.S. lifestyle clinical trials aimed at enhancing cognitive health in older adults.
Mickeal N. Key, Ashley R. Shaw, Kirk I. Erickson, Jeffrey M. Burns, Eric D. Vidoni   +4 more
doaj  

Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins

Journal of Lipid Research, 2017
Alzheimer's disease (AD) is one of the fastest-growing causes of death and disability in persons 65 years of age or older, affecting more than 5 million Americans alone.
Tien-Phat V. Huynh, Albert A. Davis, Jason D. Ulrich, David M. Holtzman   +3 more
doaj  

On the Relentless Pursuit of an Oral Insulin Delivery System: How Far is Too Far?

Advanced Therapeutics, EarlyView.
Injectable insulin preparations have far outpaced oral ones by virtue of adequate bioavailability and are driven by innovations, including insulin pumps, real‐time blood glucose monitoring, and artificial intelligence. In contrast, oral insulin delivery systems, including nanomedicines, continue to struggle and lag due to varied reasons.
Sourav Bhattacharjee
wiley   +1 more source

Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration

Advanced Science, EarlyView.
This study reveals that Kdm6a plays key roles in repressing either peripheral nervous system (PNS) or central nervous system (CNS) axon regeneration, whereas Kdm6b is not involved in regulating CNS axon regeneration. Moreover, both demethylases are able to regulate CNS neuronal survival after injury, but with non‐overlapping mechanisms.
Shu‐Guang Yang, Chang‐Ping Li, Xue‐Wei Wang, Tao Huang, Cheng Qian, Qiao Li, Ling‐Rui Zhao, Si‐Yu Zhou, Chen‐Yun Ding, Rui Nie, Saijilafu, Yu‐Cai Hong, Chang‐Mei Liu, Feng‐Quan Zhou   +13 more
wiley   +1 more source

Lymphokine Production in Patients with Alzheimer's Disease [PDF]

, 1989
H. Bessler, P. Sirota, J. Hart, M Djaldetti   +3 more
openalex   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

The public health impact of Alzheimer's disease. [PDF]

, 1987
Philip G. Weiler
openalex   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Current understanding of AD pathophysiology and impact of amyloid‐beta targeted treatments on biomarkers and clinical endpoints

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Ronald C. Petersen, Ana Graf, Maria C. Carrillo, Christopher J. Weber   +3 more
doaj   +1 more source

Asymmetry of pathology in Alzheimer's disease. [PDF]

, 1987
G K Wilcock, M M Esiri
openalex   +1 more source