Results 181 to 190 of about 9,882,917 (355)
P4‐229: Improved CSF‐based discrimination between Alzheimer's disease patients and controls after correction for ventricular volumes [PDF]
, 2015 Linda Josephine Christine van Waalwijk van Doorn +6 more
openalex +1 more source
Computer aided detection of imaging biomarkers for Alzheimer's disease
, 2021 G. S. D. Babu, B. S. Mahanand
openalex +1 more source
NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction
Advanced Science, EarlyView.NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu +15 more
wiley +1 more source
A Self‐Reinforced “Microglia Energy Modulator” for Synergistic Amyloid‐β Clearance in Alzheimer's Disease Model [PDF]
Mengmeng Ma +6 more
openalex +1 more source
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source
Genome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes
Advanced Science, EarlyView.This study explores genome‐wide by lifetime environment interactions on brain imaging phenotypes. Gene‐environment interactions explain more phenotypic variance than main effects, pinpoint regulatory variants, and reveal exposure‐specific biological pathways.
Sijia Wang +51 more
wiley +1 more source
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Ronald C. Petersen +3 more
doaj +1 more source