Results 31 to 40 of about 368,637 (232)
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules [PDF]
, 2019 Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that is associated with repetitive head impacts or exposure to blast waves. First described as punch-drunk syndrome and dementia pugilistica in retired boxers1-3, CTE has since been ...
Crowther, R. Anthony +10 more
core +1 more source
Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer\u27s disease [PDF]
, 2019 Interest in understanding the roles of white matter (WM) inflammation and damage in the pathophysiology of Alzheimer disease (AD) has been growing significantly in recent years.
Ances, Beau M +14 more
core +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Monoaminergic Neuropathology in Alzheimer's disease [PDF]
, 2017 Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira +11 more
core +1 more source
Rethinking Alzheimer’s Disease [PDF]
Frontiers in Neurology, 2012 Alzheimer’s disease (AD) is a neurodegenerative disorder with insidious onset and progressive course, which prevalence increases with the age. It is characterized by neuronal degeneration and death, related to the deposition in the brain of the amyloid β1–42 peptide and the hyperphosphorylated tau protein, and initially affects brain areas, namely the ...
openaire +4 more sources
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Smoking, dementia and cognitive decline in the elderly, a systematic review. [PDF]
, 2008 Background. Nicotine may aid reaction time, learning and memory, but smoking increases cardiovascular risk. Cardiovascular risk factors have been linked to increased risk of dementia.
Beckett, N +5 more
core +4 more sources
Treatments in Alzheimer’s disease [PDF]
Journal of Neurology, 2017 Alzheimer’s disease (AD) is the commonest cause of dementia worldwide. However, no treatment is yet available to halt or reverse the underlying pathology of established disease. Advances in the management of other common diseases and an improvement in general health have resulted in an increasingly elderly population so that the prevalence of AD is ...
Gauhar Abbas Malik, Neil Robertson
openaire +4 more sources
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source