Results 111 to 120 of about 9,943,375 (345)

The Increased Densities, But Different Distributions, of Both C3 and S100A10 Immunopositive Astrocyte-Like Cells in Alzheimer’s Disease Brains Suggest Possible Roles for Both A1 and A2 Astrocytes in the Disease Pathogenesis [PDF]

, 2020
Andrew King, Boglarka Szekely, Eda Calapkulu, Hanan Ali, Francesca Rios, Shalmai Jones, Claire Troakes   +6 more
openalex   +1 more source

TREM2 variants in Alzheimer's disease.

New England Journal of Medicine, 2013
BACKGROUND Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia.
R. Guerreiro, Aleksandra M. Wojtas, J. Bras, M. Carrasquillo, E. Rogaeva, E. Majounie, Carlos Cruchaga, C. Sassi, J. Kauwe, S. Younkin, L. Hazrati, J. Collinge, J. Pocock, T. Lashley, Julie Williams, J. Lambert, P. Amouyel, A. Goate, R. Rademakers, K. Morgan, J. Powell, P. S. St George-Hyslop, A. Singleton, J. Hardy   +23 more
semanticscholar   +1 more source

Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21‐Year Period

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations. Postmortem studies have variably, but not always, shown reduced Purkinje cell counts in essential tremor compared to controls.
Chloë A. Kerridge, Roberto S. Hernandez, Nora C. Hernandez, Phyllis L. Faust, Elan D. Louis   +4 more
wiley   +1 more source

The impact of dementia, age and sex on category fluency: Greater deficits in women with Alzheimer's disease [PDF]

, 2008
Original article can be found at: http://www.sciencedirect.com/science/journal/00109452 Copyright Elsevier Masson DOI: 10.1016/j.cortex.2007.11.008A category specific effect in naming tasks has been reported in patients with Alzheimer's dementia ...
Laws, K.R., Moreno-Martinez, F.J., Schulz, J.   +2 more
core   +1 more source

HIF-1 signalling pathway was identified as a potential new pathway for Icariin’s treatment against Alzheimer’s disease based on preclinical evidence and bioinformatics [PDF]

, 2022
Mingyao You, Ping Yuan, Liangqian Li, Hongbei Xu   +3 more
openalex   +1 more source

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source

Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias

Acta Neuropathologica Communications
Pick’s disease (PiD) is a subtype of the tauopathy form of frontotemporal lobar degeneration (FTLD-tau) characterized by intraneuronal 3R-tau inclusions.
Allegra Kawles, Rachel Keszycki, Grace Minogue, Antonia Zouridakis, Ivan Ayala, Nathan Gill, Alyssa Macomber, Vivienne Lubbat, Christina Coventry, Emily Rogalski, Sandra Weintraub, Qinwen Mao, Margaret E. Flanagan, Hui Zhang, Rudolph Castellani, Eileen H. Bigio, M.-Marsel Mesulam, Changiz Geula, Tamar Gefen   +18 more
doaj   +1 more source

Modeling Big Medical Survival Data Using Decision Tree Analysis with Apache Spark [PDF]

, 2019
In many medical studies, an outcome of interest is not only whether an event occurred, but when an event occurred; and an example of this is Alzheimer’s disease (AD).
Abdelqader, Ikhlas, Alsaedi, Abdalrahman, Altaie, Khulud, Delano, Mohammed Niaz, Fong, Alvis   +4 more
core   +1 more source

Design, synthesis, and evaluation of 8-aminoquinoline-melatonin derivatives as effective multifunctional agents for Alzheimer’s disease [PDF]

, 2022
Ziwei Chen, Xue‐Feng Yu, Lei Chen, Lexing Xu, Yu Cai, Shanshan Hou, Miaodan Zheng, Fuhe Liu   +7 more
openalex   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source