Early-onset Alzheimer’s disease due to novel LDLR gene mutation
, 2023 Romana Perković +6 more
openalex +2 more sources
Retinal biomarkers of Alzheimer’s disease: insights from transgenic mouse models [PDF]
, 2017 In this paper, we use the retina as a window into the central nervous system and in particular to assess changes in the retinal tissue associated with the Alzheimer’s disease.
Ambrósio, António F. +4 more
core +1 more source
, 2019 Figure S1. Quantitative abundances of the proteins involved in mitochondrial fusion and fission and mitoribosomes in brain proteomes of early onset AD (log2 (115/114)), late onset AD (log2 (117/116)) and healthy aging subjects (log2 (116/114)). A) iTRAQ quantitative ratios of proteins involved in mitochondrial fusion and fission, B) and C) iTRAQ ...
Adav, Sunil, Park, Jung, Siu Sze
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Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
The Role of Natural Products in Pharmacotherapy of Alzheimer’s Disease [PDF]
, 2003 Alzheimer’s disease is characterized by forgetfulness, disturbance in memory and loss of mental abilities. The final outcome of the disease is loss of personality and intellectual functions.
Singh, Amrit Pal
core +1 more source
White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines. [PDF]
, 2012 The apolipoprotein E4 (ApoE4) is an established risk factor for Alzheimer's disease (AD). Previous work has shown that this allele is associated with functional (fMRI) changes as well structural grey matter (GM) changes in healthy young, middle-aged and ...
Hampel, Harald +7 more
core +4 more sources
Increased Blood Levels of NfL, GFAP, and Placental Growth Factor After Radiotherapy to the Brain
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT In this study, we analyzed biomarkers of neuronal, glial, and vascular injury in longitudinal paired samples of blood and cerebrospinal fluid after prophylactic cranial irradiation in patients with small cell lung cancer. Neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAP) increased in serum and cerebrospinal ...
Erik Fernström +5 more
wiley +1 more source
Effect of ApoE E4 Variant on Progression from Mild Cognitive Impairment to Alzheimer’s Disease [PDF]
, 2016 Alzheimer’s disease is a very prevalent and fatal disorder in older adults, and Mild Cognitive Impairment is often seen as a precursor to Alzheimer’s disease.
Taylor, Brad P
core +1 more source
Identifying progressive imaging genetic patterns via multi-task sparse canonical correlation analysis: a longitudinal study of the ADNI cohort [PDF]
, 2019 Motivation Identifying the genetic basis of the brain structure, function and disorder by using the imaging quantitative traits (QTs) as endophenotypes is an important task in brain science.
Du, Lei +7 more
core +1 more source
, 2019 Figure S6. Negative controls for Fig. 8, panel a (Aβ1â 42 expression). Negative controls are reported in all panels marked with acronyms of secondary antibodies labeled with, respectively, Texas Red (TR) (PDF 455 kb)
Benedetto, Giulia Di +8 more
openaire +1 more source