Results 111 to 120 of about 9,392,963 (368)

Variant of TREM2 associated with the risk of Alzheimer's disease.

New England Journal of Medicine, 2013
BACKGROUND Sequence variants, including the ε4 allele of apolipoprotein E, have been associated with the risk of the common late-onset form of Alzheimer's disease.
Thorlákur Jónsson, H. Stefánsson, S. Steinberg, I. Jónsdóttir, Pálmi V. Jónsson, J. Snaedal, Sigurbjorn Bjornsson, J. Huttenlocher, A. Levey, J. Lah, D. Rujescu, H. Hampel, I. Giegling, O. Andreassen, K. Engedal, I. Ulstein, S. Djurovic, C. Ibrahim-Verbaas, A. Hofman, M. Ikram, C. V. van Duijn, U. Thorsteinsdóttir, A. Kong, K. Stefánsson   +23 more
semanticscholar   +1 more source

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy

Nature Communications
Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor
Virginia Gao, Julita Chlebowicz, Karlton Gaskin, Juan A. Briano, Lauren E. Komer, André Pineda, Shrey Jhalani, Saad Ahmad, Eseosa Uwaifo, Luca S. Black, Jillian E. Haller, Serge Przedborski, Diane A. Lane, Sheng Zhang, Manu Sharma, Jacqueline Burré   +15 more
doaj   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Living with Alzheimer’s Disease: A Wife’s Perspective [PDF]

, 1986
Bethany Chaffin
openalex   +1 more source

PND99 A STUDY OF PREFERENCES FOR DISEASE-MODIFYING TREATMENTS FOR ALZHEIMER’S DISEASE

Value in Health, 2020
H.M. Fillit, C. DeMuro, F. Mirzaei, B. Hauber, A. Dilley, C. Poulos   +5 more
openaire   +2 more sources

The neuropathological diagnosis of Alzheimer’s disease

Molecular Neurodegeneration, 2019
Alzheimer’s disease is a progressive neurodegenerative disease most often associated with memory deficits and cognitive decline, although less common clinical presentations are increasingly recognized.
M. DeTure, D. Dickson
semanticscholar   +1 more source

Controlled Magnesium Ion Delivery via Mg‐Sputtered Nerve Conduit for Enhancing Peripheral Nerve Regeneration

Advanced Healthcare Materials, EarlyView.
This study introduces a controllable degradation system for Mg‐based biomaterials using sputtering technology, marking a significant advancement in nerve regeneration research. The Mg‐sputtered nerve conduits demonstrate enhanced biocompatibility, biofunctionality, mechanical compatibility, and precise magnesium release, resulting in improved axonal ...
Hyewon Kim, Jieun Kwon, Hyeok Kim, Sunhee Lee, Seongchan Kim, Ji‐Young Lee, Khandoker Asiqur Rahaman, Taeyeon Kim, Hyojin Lee, Myoung‐Ryul Ok, Seok Chung, Hyung‐Seop Han, Yu‐Chan Kim   +12 more
wiley   +1 more source

Additional file 8: of Beneficial effects of curtailing immune susceptibility in an Alzheimerâ s disease model

, 2019
Table S1. List of all antibodies used, with respective working dilutions for either WB or IHF, as well as Companies of origin and catalog number specification. (PDF 290 kb)
Benedetto, Giulia Di, Burgaletto, Chiara, Carta, Anna, Saccone, Salvatore, Lempereur, Laurence, Mulas, Giovanna, Loreto, Carla, Bernardini, Renato, Cantarella, Giuseppina   +8 more
openaire   +1 more source

Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease.

Brain : a journal of neurology, 2009
In this study we examined changes in the large-scale structure of resting-state brain networks in patients with Alzheimer's disease compared with non-demented controls, using concepts from graph theory.
R. Helmich, M. Hallett, G. Deuschl, I. Toni, B. Bloem, N. Granger, H. Blamires, R. J. M. Franklin, N. D. Jeffery, V. Failli, M. A. Kopp, C. Gericke, P. Martus, S. Klingbeil, B. Brommer, I. Laginha, Y. Chen, M. DeVivo, U. Dirnagl, J. M. Schwab, M. Sashindranath, E. Sales, M. Daglas, R. Freeman, A. L. Samson, E. Cops, S. Beckham, A. Galle, C. Mclean, C. Morganti-Kossmann, J. V. Rosenfeld, R. Madani, J. Vassalli, Enming J Su, D. A. Lawrence, R. Medcalf, M. Starkey, C. Bleul, B. Zörner, N. T. Lindau, T. Mueggler, M. Rudin, M. Schwab, T. Doeppner, I. Młynarczuk-Biały, U. Kuckelkorn, B. Kaltwasser, J. Herz, M. R. Hasan, D. Hermann, M. Bähr, H. Sakata, P. Narasimhan, K. Niizuma, C. Maier, T. Wakai, P. H. Chan, M. M. Helmy, E. Ruusuvuori, P. V. Watkins, J. Voipio, P. Kanold, K. Kaila, E. Butti, M. Bacigaluppi, S. Rossi, M. Cambiaghi, M. Bari, A. C. Silla, E. Brambilla, A. Musella, R. de Ceglia, L. Teneud, V. De Chiara, P. D 'adamo, J. García-Verdugo, G. Comi, L. Muzio, A. Quattrini, L. Leocani, M. Maccarrone, D. Centonze, G. Martino, K. Sathe, W. Maetzler, J. D. Lang, R. B. Mounsey, C. Fleckenstein, H. L. Martin, C. Schulte, S. Mustafa, M. Synofzik, Z. Vukovic, S. Itohara, D. Berg, P. Teismann, C. Scherfler, K. Seppi, K. J. Mair, E. Donnemiller, I. Virgolini, G. Wenning, W. Poewe, L. Tönges, T. Frank, L. Tatenhorst, K. Saal, J. Koch, É. Szegõ, Jochen H Weishaupt, P. Lingor, J. Kończak, A. Sciutti, L. Avanzino, V. Squeri, M. Gori, L. Masia, G. Abbruzzese, G. Sandini, H. Tsuji, T. Arai, F. Kametani, T. Nonaka, M. Yamashita, M. Suzukake, M. Hosokawa, M. Yoshida, H. Hatsuta, M. Takao, Y. Saito, S. Murayama, H. Akiyama, M. Hasegawa, D. M. A. Mann, A. Tamaoka, D. S. Pitceathly, C. Smith, C. Fratter, C. Alston, L. He, K. Craig, E. Blakely, J. Evans, J. Taylor, Z. Shabbir, M. Deschauer, U. Pohl, M. Roberts, M. C. Jackson, C. Halfpenny, P. Turnpenny, P. W. Lunt, M. Hanna, A. Schaefer, R. Mcfarland, R. Horvath, P. Chinnery, D. Turnbull, J. Poulton, R. Taylor, G. Gorman, D. Ronchi, C. Garone, A. Bordoni, P. G. Rios, S. E. Calvo, M. Ripolone, M. Ranieri, M. Rizzuti, L. Villa, F. Magri, S. Corti, N. Bresolin, V. Mootha, M. Moggio, S. Dimauro, G. Comi, M. Sciacco, D. Cazzoli, R. Müri, R. Schumacher, S. von Arx, S. Chaves, K. Gutbrod, S. Bohlhalter, D. Bauer, T. Vanbellingen, M. Bertschi, S. Kipfer, C. R. Rosenthal, C. Kennard, C. Bassetti, T. Nyffeler, Brain   +193 more
semanticscholar   +1 more source