Mitochondrial links between brain aging and Alzheimer’s disease
Translational Neurodegeneration, 2021 Advancing age is a major risk factor for Alzheimer’s disease (AD). This raises the question of whether AD biology mechanistically diverges from aging biology or alternatively represents exaggerated aging.
Heather M. Wilkins, Russell H. Swerdlow
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Additional file 3: of The neuropathological diagnosis of Alzheimerâ s disease
, 2019 Figure S3. Pathologic Diagnoses in 626 Patients with Clinical Diagnosis of AD. The majority of clinical AD cases as observed in the Mayo Clinic Brain Bank from 2007 to 2016 were found to have co-pathologies. (PPTX 63 kb)
DeTure, Michael, Dickson, Dennis
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The role of mutation rate variation and genetic diversity in the architecture of human disease [PDF]
, 2013 We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all genes that could cause disease have already been identified ...
arxiv +1 more source
Diet moderates the effect of resting state functional connectivity on cognitive function
Scientific Reports, 2022 Past research suggests modifiable lifestyle factors impact structural and functional measures of brain health, as well as cognitive performance, but no study to date has tested the effect of diet on resting state functional connectivity (rsFC), and its ...
Alexandra M. Gaynor +8 more
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Mixture of Input-Output Hidden Markov Models for Heterogeneous Disease Progression Modeling [PDF]
arXiv, 2022 A particular challenge for disease progression modeling is the heterogeneity of a disease and its manifestations in the patients. Existing approaches often assume the presence of a single disease progression characteristics which is unlikely for neurodegenerative disorders such as Parkinson's disease.
arxiv
The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults
Alzheimer’s Research & Therapy, 2023 Background Insulin resistance (IR) and type 2 diabetes have been found to increase the risk for Alzheimer’s clinical syndrome in epidemiologic studies but have not been associated with tau tangles in neuropathological research and have been ...
Gilda E. Ennis +7 more
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MOESM1 of Plasma lipoproteome in Alzheimerâ s disease: a proof-of-concept study
, 2018 Additional file 1. Supplementary methods.
Li, Danni +7 more
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Relationship between afternoon napping and cognitive function in the ageing Chinese population
General Psychiatry, 2021 Background Several studies have shown that afternoon napping promotes cognitive function in the elderly; on the other hand, some studies have shown opposite results.
Wei Li +5 more
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The Effect of Disease-induced Mortality on Structural Network Properties [PDF]
PLoS ONE, 10, e0136704 (2015), 2015 As the understanding of the importance of social contact networks in the spread of infectious diseases has increased, so has the interest in understanding the feedback process of the disease altering the social network. While many studies have explored the influence of individual epidemiological parameters and/or underlying network topologies on the ...
arxiv +1 more source
Phase diagram of epidemic spreading - unimodal vs. bimodal probability distributions [PDF]
, 2009 The disease spreading on complex networks is studied in SIR model. Simulations on empirical complex networks reveal two specific regimes of disease spreading: local containment and epidemic outbreak. The variables measuring the extent of disease spreading are in general characterized by a bimodal probability distribution.
arxiv +1 more source