Results 41 to 50 of about 9,943,375 (345)

Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup

Alzheimer's & Dementia
The National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis and characterization of Alzheimer's disease (AD).
Clifford R Jack, J. S. Andrews, Thomas G. Beach, Teresa Buracchio, B. Dunn, Ana Graf, Oskar Hansson, Carole Ho, William Jagust, E. McDade, J. Molinuevo, O. Okonkwo, Luca Pani, M. Rafii, P. Scheltens, Eric R. Siemers, H. Snyder, R. Sperling, C. Teunissen, Maria C. Carrillo   +19 more
semanticscholar   +1 more source

Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

Molecules, 2020
Alzheimer’s disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline in thinking and independence in personal daily activities.
Zeinab Breijyeh, R. Karaman
semanticscholar   +1 more source

Forecasting the progression of Alzheimer's disease using neural networks and a novel preprocessing algorithm

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019
Introduction There is a 99.6% failure rate of clinical trials for drugs to treat Alzheimer's disease, likely because Alzheimer's disease (AD) patients cannot be easily identified at early stages. This study investigated machine learning approaches to use
Jack Albright, Alzheimer's Disease Neuroimaging Initiative   +1 more
doaj   +1 more source

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

Molecular Neurodegeneration, 2018
Background β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patients.
WonHee Kim, Liang Ma, Selene Lomoio, Rachel Willen, Sylvia Lombardo, Jinghui Dong, Philip G. Haydon, Giuseppina Tesco   +7 more
doaj   +1 more source

Diverse Roles of Ceramide in the Progression and Pathogenesis of Alzheimer’s Disease

Biomedicines, 2022
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and is associated with several pathophysiological features, including cellular dysfunction, failure of neurotransmission, cognitive impairment, cell death, and other clinical ...
Md Riad Chowdhury, Hee Kyung Jin, Jae-sung Bae   +2 more
doaj   +1 more source

Escala de Avaliação da Doença de Alzheimer – Subescala cognitiva (ADAS-Cog): Dados normativo para a população portuguesa [PDF]

, 2017
Introduction: The Alzheimer’s Disease Assessment Scale – Cognitive Subscale is a brief battery developed to assess cognitive functioning in Alzheimer’s disease that encompasses the core characteristics of cognitive decline (e.g. memory, language, praxis, 
Almeida, Jorge, Duro, Diana, Freitas, Sandra, Guerreiro, Manuela, Nogueira, Joana, Santana, Isabel, Tábuas-Pereira, Miguel   +6 more
core   +2 more sources

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Lower hippocampal volume is associated with late‐life cognitive decline and is an important, but nonspecific marker for clinical Alzheimer's dementia. Cerebrovascular disease may also be associated with hippocampal volume.
Alifiya Kapasi, Ana W. Capuano, Melissa Lamar, Sue E. Leurgans, Arnold M. Evia, David A. Bennett, Konstantinos Arfanakis, Julie A. Schneider   +7 more
doaj   +1 more source

2024 Alzheimer's disease facts and figures

Alzheimer's & Dementia
This article describes the public health impact of Alzheimer's disease (AD), including prevalence and incidence, mortality and morbidity, use and costs of care and the ramifications of AD for family caregivers, the dementia workforce and society.

semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source