Results 271 to 280 of about 25,152,973 (316)

TRPC3‐Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons

Advanced Science, EarlyView.
How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu, Jianbo Zhao, Zhenli Xie, Yuan Wang, Ruolin Wang, Bianbian Wang, Chuhan Shen, Yali Chen, Jingyu Yao, Ziyang Li, Huadong Xu, Zuying Chai, Zhuoyu Zhang, Changhe Wang, Rong Huang   +14 more
wiley   +1 more source

DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimer´s disease. [PDF]

Cell Mol Life Sci
Jąkalski M, Bruhn-Olszewska B, Rychlicka-Buniowska E, Davies H, Sarkisyan D, Siedlar M, Baran J, Węglarczyk K, Jaszczynski J, Ryś J, Gedraitis V, Filipowicz N, Klich-Rączka A, Kilander L, Ingelsson M, Dumanski JP.   +15 more
europepmc   +1 more source

Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease. [PDF]

Mol Psychiatry
Mengel D, Soter E, Ott JM, Wacker M, Leyva A, Peters O, Hellmann-Regen J, Schneider LS, Wang X, Priller J, Spruth E, Altenstein S, Schneider A, Fliessbach K, Wiltfang J, Hansen N, Rostamzadeh A, Düzel E, Glanz W, Incesoy EI, Buerger K, Janowitz D, Ewers M, Perneczky R, Rauchmann B, Teipel S, Kilimann I, Laske C, Sodenkamp S, Spottke A, Brustkern J, Brosseron F, Wagner M, Stark M, Kleineidam L, Shao K, Lüsebrink F, Yakupov R, Schmid M, Hetzer S, Dechent P, Scheffler K, Berron D, Jessen F, Synofzik M, DELCODE study group.   +45 more
europepmc   +1 more source

Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease. [PDF]

J Neuroimmune Pharmacol
Mengr A, Šmotková Z, Pačesová A, Železná B, Kuneš J, Maletínská L.   +5 more
europepmc   +1 more source

Alkaloids from Caliphruria subedentata (Amaryllidaceae) as Regulators of AChE, BuChE, NMDA and GSK3 Activity: An In Vitro and In Silico Approach for Mimicking Alzheimer´s Disease. [PDF]

Neurochem Res
Ordoñez WOC, Palomino NV, Varela PEV, Martínez IB, Alves LB, Giuliatti S.   +5 more
europepmc   +1 more source