Results 151 to 160 of about 444,470 (282)

Global studies in social determinants of health in people with Alzheimer´s disease [PDF]

Maryenela Illanes‐Manrique, Pilar Giron‐Davila, Larry D Adams, Sheila Castro‐Suarez, Julia Ríos‐Pinto, Pedro Mena, Elison Sarapura‐Castro, Farid Rajabli, Ivan Cornejo‐Herrera, Katalina McInerney, Michael L. Cuccaro, Jeffery M. M Vance, Angel Medina‐Colque, Koni Mejia‐Rojas, Edward Ochoa‐Valle, Serggio Lanata, Aldo Vences‐Balta, Eden R. Martin, Giuseppe Tosto, Margaret Pericak‐Vance, Mario Cornejo‐Olivas   +20 more
openalex   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Características da doença de Alzheimer e abordagem aos cuidadores

, 2023
Ednardo Fornanciari Antunes, Roberto Rosa Cabral, Simone Dalbem de Souza, Vanessa Jovis dos Santos, Reili de Fátima dos Santos, Omar Ariel Espinosa   +5 more
openalex   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Impact and Therapeutic Potential of PPARs in Alzheimers Disease

, 2011
Michael T. Heneka, Elisabet Reyes-Irisarri, Michael Hull, Markus P. Kummer   +3 more
openalex   +2 more sources

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease [PDF]

, 2012
Rashid Deane, Itender Singh, Abhay P. Sagare, Robert D. Bell, Nathan T. Ross, Barbra LaRue, Rachal Love, Sheldon Perry, Nicole Paquette, Richard J. Deane, Meenakshisundaram Thiyagarajan, Troy J. Zarcone, G. Fritz, Alan E. Friedman, Benjamin L. Miller, Berislav V. Zloković   +15 more
openalex   +1 more source

Olfactory‐to‐Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency‐Specific Oscillatory Decoupling

Advanced Science, EarlyView.
Wang et al reveal that in the olfactory system, the selective impairment of gamma‐driven Barcode features underlying early olfactory deficits, while the selective impairment of theta‐driven Barcode features underlying later cognitive deficits, further establishing cross‐network gamma oscillations in the early stage as a biomarker of later cognitive ...
Shuaishuai Wang, Zhishen Cai, Xingfeng Mao, Yixuan Zhang, Yunlong Pan, Jiawen Cheng, Xuechun Wang, Hengyi Song, Sasaki Takuya, Ming Lu, Gang Hu, Xiuxiu Liu, Yingmei Lu, Feng Han   +13 more
wiley   +1 more source

Exploring the Delivery and Management of Specialised Post-Diagnostic Care and Support in Young-Onset Dementia: A Cross-Sectional Study. [PDF]

Health Serv Insights
van Westendorp S, Hofman C, Mortier M, Appelhof B, Gerring P, Koopmans R, Bakker C.   +6 more
europepmc   +1 more source

Rigid Hollow Microparticles for Enhanced Focused Ultrasound Treatment Under Optoacoustic Guidance

Advanced Science, EarlyView.
By combining focused ultrasound (FUS) and acoustically active hollow borosilicate microparticles (HBMPs), we demonstrate tunable control over interparticle dynamics and their localized thermal energy deposition. Modulation of acoustic frequency and particle concentration tailors the energy delivery, allowing adaptive, material‐based regulation of ...
Nima Mahkam, Yi Chen, Héctor Estrada, Ananya Amitabh, Amirreza Aghakhani, Metin Sitti, Daniel Razansky   +6 more
wiley   +1 more source