Results 151 to 160 of about 158,526 (239)

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Harmonized Protocol for Subfield Segmentation in the Hippocampal Body on High-Resolution In Vivo MRI From the Hippocampal Subfields Group (HSG). [PDF]

Hippocampus
Daugherty AM, Carr V, Canada KL, Rådman G, Brown T, Augustinack J, Amunts K, Bakker A, Berron D, Burggren A, Chetelat G, de Flores R, Ding SL, Huang Y, Johnson E, Kanel P, Keresztes A, Kedo O, Kennedy KM, Lee J, Malykhin N, Martinez A, Mueller S, Mulligan E, Ofen N, Palombo D, Pasquini L, Pluta J, Raz N, Riggins T, Rodrigue KM, Saifullah S, Schlichting ML, Stark C, Wang L, Yushkevich P, La Joie R, Wisse L, Olsen R, Alzheimer’s Disease Neuroimaging Initiative, Hippocampal Subfields Group.   +40 more
europepmc   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

CSF Proteomic Profiles Associated With White Matter Integrity in Cognitively Normal Older Adults With and Without Amyloid Pathology. [PDF]

Neurology
Lorenzini L, Tranfa M, Kate MT, Braber AD, Vermunt L, Duits FH, Lageman SB, de Leeuw D, Teunissen CE, Garbarino S, Roccatagliata L, Pardini M, Van Der Flier WM, Visser PJ, Barkhof F, Tijms BM.   +15 more
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

What is the psychological and cognitive impact of returning Alzheimer disease dementia research results to healthy research participants? a delayed-start randomised clinical trial protocol for the WeSHARE study (Washington University study of having Alzheimer disease <b>r</b>esearch results explained). [PDF]

BMJ Open
Hartz SM, Goswami S, Oliver A, Evans A, Jackson S, Linnenbringer E, Moulder KM, Morris JC, Mozersky J.   +8 more
europepmc   +1 more source

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, EarlyView.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

The TBI-AD/ADRD Caregiver Support Intervention (TACSI): Protocol of a Pilot Randomized Controlled Trial Evaluation of a Remote Intervention for Family Caregivers.

JMIR Res Protoc
Ostenso S, Birkeland RW, Albers E, Louwagie KW, Iwan A, Chesak SS, Gaugler JE.   +6 more
europepmc   +1 more source

A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection

Advanced Science, EarlyView.
A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Marcia Domínguez, David Azorín‐Soriano, Araceli Lérida‐Viso, Jessie García‐Fleitas, Paula M Soriano‐Teruel, Jennifer Soler Beatty, Paula Rodrigo‐Martínez, Pau Arroyo, Sara Rojas‐Vázquez, Isabel Fariñas, Félix Sancenón, Juan F. Blandez, Alba García‐Fernández, Ramón Martínez‐Máñez   +13 more
wiley   +1 more source

Longitudinal changes of blood β-synuclein in cognitively unimpaired, mild cognitive impairment and sporadic Alzheimer´s disease. [PDF]

Alzheimers Res Ther
Oeckl P, Abu-Rumeileh S, Weise CM, Otto M, Alzheimer’s Disease Neuroimaging Initiative.   +4 more
europepmc   +1 more source