Results 81 to 90 of about 530,865 (344)

Powder Metallurgy Preparation of Metastable β Ti–Cr–Ge Alloys for Medical Applications

open access: yesAdvanced Engineering Materials, EarlyView.
This study develops metastable β Ti–Cr–Ge alloys using powder metallurgy for biomedical implants. The Ti–10Cr–2Ge alloy exhibits superior mechanical performance with high yield strength (>1100 MPa), low Young's modulus (<85 GPa), and excellent strain hardening behavior.
Teddy Sjafrizal   +3 more
wiley   +1 more source

Photothermal Hydrogel with Mn3O4 Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism

open access: yesAdvanced Functional Materials, EarlyView.
The MPTT‐nanozyme‐hydrogel system (Mn3O4@ChS‐HA) provides a multifunctional therapeutic strategy for intervertebral disc degeneration (IVDD), effectively targeting oxidative stress and enhancing AF repair by restoring extracellular matrix (ECM) and redox homeostasis.
Yangyang Chen   +13 more
wiley   +1 more source

Auditory Agnosia and Alzheimer's Disease: a Cohort Study

open access: yesRevista Finlay, 2023
Foundation: recent evidence suggests that disorders caused by the onset of Alzheimer's disease can cause sound agnosia. Objective: to investigate whether patients with mild cognitive impairment and dementia as a symptom of Alzheimer's recognize ...
Manuel Conrado Ezcurdia Bárzaga   +2 more
doaj  

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

open access: yesAdvanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim   +8 more
wiley   +1 more source

Investigating Acetylcholinesterase Inhibitory Effects of some Ferula Species

open access: yesJournal of Medicinal Plants, 2013
Background: Nowadays, one of the methods for treatment of Alzheimer is using of acetylcholinesterase inhibitors (AChEIs). Discovering the drugs with better effects and fewer side effects especially from natural sources is the aim of many researchers ...
M Shekarchi   +4 more
doaj  

Social robots in advanced dementia

open access: yesFrontiers in Aging Neuroscience, 2015
Aims: Testing the effect of the experimental robot-based therapeutic sessions for patients with dementia in: a controlled study of parallel groups of nursing home patients comparing the effects of therapy sessions utilizing a humanoid robot (NAO), an ...
Meritxell eValentí Soler   +18 more
doaj   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

open access: yesAdvanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan   +4 more
wiley   +1 more source

Report summary - Prevalence and monetary costs of dementia in Canada (2016): a report by the Alzheimer Society of Canada

open access: yesHealth Promotion and Chronic Disease Prevention in Canada, 2016
null
Alzheimer Society of Canada
doaj   +1 more source

Engineering a Single Amino Acid Bionanozyme for Ultrasensitive Detection of Biomarkers: A WHO‐REASSURE‐ Aligned Approach

open access: yesAdvanced Functional Materials, EarlyView.
A unique 2D bionanozyme, engineered from a single amino acid and copper ions, demonstrates peroxidase‐mimicking catalytic activity. This efficient and simple bionanozyme allows for ultrasensitive, equipment‐free visual detection of key biomarkers in both test and real samples, meeting the WHO‐REASSURE standards for practical diagnostic applications ...
Subrat Vishwakarma   +5 more
wiley   +1 more source

Integrated Genome-Wide Analysis of DNA Methylation and Gene Expression in the Hippocampi of 5xFAD Alzheimer’s Disease Mouse Model

open access: yesJournal of Integrative Neuroscience
Background: DNA methylation forms 5-methylcytosine and its regulation in the hippocampus is critical for learning and memory. Indeed, dysregulation of DNA methylation is associated with neurological diseases.
Sueun Lee   +7 more
doaj   +1 more source

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