Results 71 to 80 of about 461,295 (348)

ADVANCEMENTS IN ALZHEIMER’S DIAGNOSIS THROUGH MRI USING BAYESIAN CONVOLUTIONAL NEURAL NETWORKS AND VARIATIONAL INFERENCE

Barekeng
Alzheimer’s disease is one of the brain disorders that can be deadly in older. The disease is less treated and less recognized, but Alzheimer’s disease is now a significant public health problem.
Alifia Ardha Nareswari, Dina Tri Utari
doaj   +1 more source

Uncovering potential neuroprotective flavonoids for Alzheimer's disease using cutting-edge molecular simulation and in vitro SHSY-5Y analysis [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Alzheimer's disease (AD) is a debilitating neurodegenerative condition primarily afflicting the elderly, causing a progressive decline in cognitive function.
Fadilah Fadilah, Immanuelle Kezia, Linda Erlina   +2 more
doaj   +1 more source

Mapping the genetic landscape of early-onset Alzheimer’s disease in a cohort of 36 families

Alzheimer’s Research & Therapy, 2022
Background Many families with clinical early-onset Alzheimer’s disease (EOAD) remain genetically unexplained. A combination of genetic factors is not standardly investigated.
Merel O. Mol, Sven J. van der Lee, Marc Hulsman, Yolande A. L. Pijnenburg, Phillip Scheltens, Netherlands Brain Bank, Harro Seelaar, John C. van Swieten, Laura Donker Kaat, Henne Holstege, Jeroen G. J. van Rooij   +10 more
doaj   +1 more source

The interaction of amyloid A beta(1-40) with lipid bilayers and ganglioside as studied by P-31 solid-state NMR [PDF]

, 2009
Amyloid P-peptide (A beta) is a major component of plaques in Alzheimer's disease, and formation of senile plaques has been suggested to originate fro m regions of neuronal membrane rich in gangliosides. We analyzed the mode of interaction of A beta with
Asakura, T., Nakazawa, Y., Saito, H., Suzuki, Y., Williamson, M.P.   +4 more
core   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

¿Vivir en/entre sonrisas? Envejecimiento y Alzheimer. / To live in/among smiles? Aging and Alzheimer.

Novedades en Población, 2021
This research characterizes the demographic aging in the Artemisa province in the year 2018. The analysis is built from the calculation of demographic indicators that allow the stablishment of an interrelation among ages.
Sahilí Cristiá Lara, Leonardo Cristiá Lara   +1 more
doaj  

Identifying dementia using medical data linkage in a longitudinal cohort study: Lothian Birth Cohort 1936

BMC Psychiatry, 2023
Background The Lothian Birth Cohort 1936 (LBC1936) is a longitudinal study of ageing with well-characterised assessments, but until now, it has relied on self-report or proxies for dementia such as cognitive tests. Our aims were twofold: a) to describe a
Donncha S. Mullin, Lucy E. Stirland, Emily Buchanan, Catherine-Anne Convery, Simon R. Cox, Ian J. Deary, Cinzia Giuntoli, Holly Greer, Danielle Page, Elizabeth Robertson, Susan D. Shenkin, Anna Szalek, Adele Taylor, Georgina Weatherdon, Tim Wilkinson, Tom C. Russ   +15 more
doaj   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Cognitive impairment in older people: its implications for future demand for services and costs [PDF]

, 2003
This study aimed to make projections, for the next 30 years, of future numbers of older people with cognitive impairment, their demand for long-term care services and the future costs of their care under a range of specified assumptions.

core  

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome [PDF]

, 2018
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles.
Arena, Andrea, Barone, Eugenio, Blarzino, Carla, Butterfield, D. Allan, Di Domenico, Fabio, Lanzillotta, Chiara, Mosca, Luciana, Perluigi, Marzia, Tramutola, Antonella, Zuliani, Ilaria   +9 more
core   +3 more sources