Results 61 to 70 of about 461,295 (348)
BarekengThis study addresses the ongoing challenge of clarifying the risk factors contributing to Alzheimer's disease, a neurodegenerative condition marked by progressive cognitive decline and memory dysfunction, with cases rising globally.
Ardi Kurniawan +3 more
doaj +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Alzheimer’s Research & TherapyIntroduction Optical coherence tomography angiography (OCT-A) is a novel tool that allows the detection of retinal vascular changes. We investigated the association of macular vessel density (VD) in the superficial plexus assessed by OCT-A with measures ...
Ainhoa García-Sánchez +29 more
doaj +1 more source
Alternative therapies: challenging Alzheimer
INFAD, 2019 Introduction; Alzheimer’s disease is the most frequent cause of dementia. It is a neurodegenerative disease that causes difficulty in remembering recent events.
Marta Sánchez Martín +8 more
doaj +1 more source
Statistics and society: a study on the burden experienced by caregivers of patients with Alzheimer [PDF]
, 2007 The cost of caring for people with Alzheimer-type diseases is enormous. Caregivers experience emotional, physical and financial stress, and their demands are central to decisions on patient institutionalization.
Papacostas, Savvas S. +2 more
core +1 more source
Cerebrospinal Fluid Tau Protein Levels and F-18-Fluorodeoxyglucose Positron Emission Tomography in the Differential Diagnosis of Alzheimer's Disease [PDF]
, 2010 Aims: In this study, we aimed to compare cerebrospinal fluid (CSF) levels of total tau (t-tau), phosphorylated tau (p-tau(181)) and positron emission tomography with F-18-fluorodeoxyglucose (FDG-PET) in the differential diagnosis of Alzheimer's disease ...
Bartenstein, Peter +7 more
core +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
What Can Quantitative Gait Analysis Tell Us about Dementia and Its Subtypes? A Structured Review [PDF]
, 2017 Distinguishing dementia subtypes can be difficult due to similarities in clinical presentation. There is increasing interest in discrete gait characteristics as markers to aid diagnostic algorithms in dementia.
Galna, Brook +5 more
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung +7 more
wiley +1 more source
Beilstein Journal of Organic ChemistryThe ongoing quest to discover effective treatments for diseases remains a significant challenge for the scientific community. Multicomponent reactions (MCRs) have emerged as powerful tools in accelerating drug discovery, enabling the rapid generation of ...
Lucía Campos-Prieto +3 more
doaj +1 more source