Results 51 to 60 of about 461,295 (348)

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Changes in choroidal thickness quantified by Optical Coherence Tomography across cognitive impairment: data from the NORFACE cohort

Alzheimer’s Research & Therapy
Background Optical coherence tomography (OCT) enables high-resolution imaging of ocular structures in health and disease. Choroid thickness (CT) is a key vascular retinal parameter that can be assessed by OCT and might be relevant in the evaluation of ...
Luis Castilla-Martí, Ainhoa García-Sánchez, Joan Martínez, Maitée Rosende-Roca, Liliana Vargas, Juan Pablo Tartari, Federico Casales, José Nelet Rodríguez, Natali Bein, Montserrat Alegret, Gemma Ortega, Ana Espinosa, Ángela Sanabria, Alba Pérez-Cordón, Nathalia Muñoz, Fernando García-Gutiérrez, Josep Blazquez-Folch, Andrea Miguel, Itziar de Rojas, Pablo García-González, Raquel Puerta, Clàudia Olivé, Maria Capdevila, Álvaro Muñoz-Morales, Paula Bayón-Buján, Amanda Cano, Victoria Fernández, Sergi Valero, Lluís Tárraga, Agustín Ruiz, Mercè Boada, Miguel Castilla-Martí, Marta Marquié   +32 more
doaj   +1 more source

The Notebook: An Accidental Alzheimer\u27s Awareness Campaign [PDF]

, 2014
My paper examines and critiques the portrayal of Alzheimer¹s disease in the popular film, The Notebook. Based off of a Nicholas Sparks novel, The Notebook uses Alzheimer¹s disease as a vehicle to relay a love story, but in doing so, presents a distorted ...
Waldron, Danielle
core   +1 more source

Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer\u27s disease [PDF]

, 2019
Interest in understanding the roles of white matter (WM) inflammation and damage in the pathophysiology of Alzheimer disease (AD) has been growing significantly in recent years.
Ances, Beau M, Benzinger, Tammie L.S., Blazey, Tyler, Cairns, Nigel J, Chen, Charlie, Cruchaga, Carlos, Fagan, Anne M, Gordon, Brian A, Liu, Jingxia, Morris, John C, Shimony, Joshua S, Su, Yi, Sutphen, Courtney L, Wang, Qing, Wang, Yong   +14 more
core   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Genome-wide association study and polygenic risk scores of retinal thickness across the cognitive continuum: data from the NORFACE cohort

Alzheimer’s Research & Therapy
Background Several studies have reported a relationship between retinal thickness and dementia. Therefore, optical coherence tomography (OCT) has been proposed as an early diagnosis method for Alzheimer’s disease (AD).
María Eugenia Sáez, Ainhoa García-Sánchez, Itziar de Rojas, Emilio Alarcón-Martín, Joan Martínez, Amanda Cano, Pablo García-González, Raquel Puerta, Clàudia Olivé, Maria Capdevila, Fernando García-Gutiérrez, Miguel Castilla-Martí, Luis Castilla-Martí, Ana Espinosa, Montserrat Alegret, Mario Ricciardi, Vanesa Pytel, Sergi Valero, Lluís Tárraga, Mercè Boada, Agustín Ruiz, Marta Marquié   +21 more
doaj   +1 more source

14th Panhellenic Conference on Alzheimer’s Disease and the 6th Mediterranean Conference on Neurodegenerative Diseases, 13 February–16 February, Thessaloniki, Greece

NeuroSci
At the 14th Panhellenic Conference on Alzheimer’s Disease and 6th Mediterranean Conference on neurodegenerative diseases, we experienced an exciting journey, following the patient through the stages of their neurodegenerative disease: onset, diagnosis ...
Magda Tsolaki
doaj   +1 more source

Investigation of the anti-amyloidogenic and antioxidant effects of silver nanoparticles synthesised with leaf extract of Thymus kotschyanus Boiss [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2023
Introduction: The extract of Thymus kotschyanus Boiss, in addition to its antioxidant properties, also has a marvellous anti-amyloidogenic effectthat can be used for the treatment of amyloidosis.
Zolfaghar Lotfi, Fatemeh Maleki, Somayeh Farahmand   +2 more
doaj  

Visual Molecular Dynamics Investigations of the Impact of Hydrophobic Nanoparticles on Prognosis of Alzheimer’s Disease and Cancers [PDF]

, 2012
The possible impact of hydrophobic lectin nanoparticles on the prognosis and progression of Alzheimer's disease (AD) and cancers was investigated by Visual Molecular Dynamics (VMD) computer modeling programs available from the Beckmann Advanced ...
I. C. Baianu, M Charles, V. I. Prisecaru
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source