Results 211 to 220 of about 9,708,599 (370)
Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro +28 morewiley +1 more sourceAmyloid-β Precursor Protein Modulates the Sorting of Testican-1 and Contributes to Its Accumulation in Brain Tissue and Cerebrospinal Fluid from Patients with Alzheimer Disease
, 2016 Álvaro Barrera-Ocampo, Sönke Arlt, Jakob Matschke, Ursula Hartmann, Berta Puig, Isidró Ferrer, Petra Zürbig, Markus Glatzel, Diego Sepúlveda‐Falla, Holger Jahn +9 moreopenalex +2 more sourcesCircular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Advanced Science, EarlyView.Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu +16 morewiley +1 more sourceSimultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer\u27s disease [PDF]
, 2018 Aschenbrenner, Andrew J, Bateman, Randall J, Benzinger, Tammie L.S., Fagan, Anne M, Gordon, Brian A, Hassenstab, Jason, Li, Yan, McDade, Eric M, Morris, John C, the Dominantly Inherited Alzheimer Network (DIAN),, Wang, Guoqiao, Xiong, Chengjie +11 morecore +2 more sourcesMeta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Nature Genetics, 2013 J. Lambert, C. Ibrahim-Verbaas, D. Harold, A. Naj, R. Sims, C. Bellenguez, G. Jun, A. Destefano, J. Bis, G. Beecham, B. Grenier‐Boley, G. Russo, T. Thornton-Wells, N. Jones, A. Smith, V. Chouraki, C. Thomas, M. Ikram, D. Zélénika, B. Vardarajan, Y. Kamatani, Chiao-Feng Lin, A. Gerrish, H. Schmidt, B. Kunkle, M. Dunstan, A. Ruiz, M. Bihoreau, S. Choi, C. Reitz, F. Pasquier, P. Hollingworth, A. Ramírez, O. Hanon, A. Fitzpatrick, J. Buxbaum, D. Campion, P. Crane, C. Baldwin, T. Becker, V. Gudnason, C. Cruchaga, D. Craig, N. Amin, C. Berr, O. Lopez, P. D. Jager, V. Deramecourt, J. Johnston, D. Evans, S. Lovestone, L. Letenneur, F. Morón, D. Rubinsztein, G. Eiriksdottir, K. Sleegers, A. Goate, N. Fievet, M. Huentelman, M. Gill, K. Brown, M. Kamboh, L. Keller, P. Barberger‐Gateau, B. McGuinness, E. Larson, R. Green, A. Myers, C. Dufouil, S. Todd, D. Wallon, S. Love, E. Rogaeva, J. Gallacher, P. George-Hyslop, J. Clarimón, A. Lleó, A. Bayer, D. Tsuang, Lei Yu, M. Tsolaki, P. Bossù, G. Spalletta, P. Proitsi, J. Collinge, S. Sorbi, F. Sánchez-García, Nick C Fox, J. Hardy, M. Naranjo, P. Bosco, R. Clarke, C. Brayne, D. Galimberti, M. Mancuso, F. Matthews, S. Moebus, P. Mecocci, M. Zompo, W. Maier, H. Hampel, A. Pilotto, M. Bullido, F. Panza, P. Caffarra, B. Nacmias, J. Gilbert, M. Mayhaus, L. Lannfelt, H. Hakonarson, S. Pichler, M. Carrasquillo, M. Ingelsson, D. Beekly, V. Álvarez, F. Zou, O. Valladares, S. Younkin, E. Coto, K. Hamilton-Nelson, W. Gu, C. Razquín, P. Pastor, I. Mateo, M. Owen, K. Faber, P. Jonsson, O. Combarros, M. O’Donovan, L. Cantwell, H. Soininen, D. Blacker, S. Mead, T. Mosley, D. Bennett, T. Harris, L. Fratiglioni, C. Holmes, R. F. Bruijn, P. Passmore, T. Montine, K. Bettens, J. Rotter, A. Brice, K. Morgan, T. Foroud, W. Kukull, D. Hannequin, J. Powell, M. Nalls, K. Ritchie, K. Lunetta, J. Kauwe, E. Boerwinkle, M. Riemenschneider, M. Boada, M. Hiltunen, E. Martin, R. Schmidt, D. Rujescu, Li-San Wang, J. Dartigues, R. Mayeux, C. Tzourio, A. Hofman, M. Nöthen, C. Graff, B. Psaty, L. Jones, J. Haines, P. Holmans, M. Lathrop, M. Pericak-Vance, L. Launer, L. Farrer, C. Duijn, C. Broeckhoven, V. Moskvina, S. Seshadri, Julie Williams, G. Schellenberg, P. Amouyel +181 moresemanticscholar +1 more sourceConstruction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs
Advanced Science, EarlyView.This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi +31 morewiley +1 more sourceDefective Tumor Necrosis Factor-α-dependent Control of Astrocyte Glutamate Release in a Transgenic Mouse Model of Alzheimer Disease [PDF]
, 2005 Daniela Rossi, Liliana Brambilla, Chiara F. Valori, Andrea Crugnola, Giorgio Giaccone, Raffaella Capobianco, Michela Mangieri, Ann E. Kingston, Alain Bloc, Paola Bezzi, Andrea Volterra +10 moreopenalex +1 more source
