Results 201 to 210 of about 362,575 (339)

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

Immune-proteo-metabolomic changes link to Aβ and tau pathology in Alzheimer disease. [PDF]

Alzheimers Dement
Wang M, Buthut M, Meinhardt J, Otto C, Gallaccio G, Fernández-Zapata C, Teves M, Samol C, Dettmer K, Heckscher S, Kamboj S, Bahar Y, Conrad C, Böttcher C, Kunkel D, Ruprecht K, Paul F, Oefner PJ, Radbruch H, Gronwald W, Prüß H, Böttcher C.   +21 more
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source

Anemia and Blood Biomarkers of Alzheimer Disease in Dementia Development.

JAMA Netw Open
Valletta M, Vetrano DL, Qiu C, Canevelli M, Miccoli E, Andersson S, Fredolini C, Bruno G, Winblad B, Fratiglioni L, Grande G.   +10 more
europepmc   +1 more source

Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease

, 2019
Jing Tian, Lan Guo, Shaomei Sui, Christopher Driskill, Aarron Phensy, Qi Wang, Esha Gauba, Jeffrey M. Zigman, Russell H. Swerdlow, Sven Kroener, Heng Du   +10 more
openalex   +2 more sources

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, EarlyView.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

Neuropsychiatric Symptoms in Patients With Pathologically Confirmed Comorbid Alzheimer Disease and Frontotemporal Lobar Degeneration. [PDF]

Neurology
Ross D, Split M, Kunicki Z, Keszycki R, Prieto S, De Vito AN, Manoochehri M, Huey ED, Barker MS.   +8 more
europepmc   +1 more source

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease [PDF]

, 2012
Rashid Deane, Itender Singh, Abhay P. Sagare, Robert D. Bell, Nathan T. Ross, Barbra LaRue, Rachal Love, Sheldon Perry, Nicole Paquette, Richard J. Deane, Meenakshisundaram Thiyagarajan, Troy J. Zarcone, G. Fritz, Alan E. Friedman, Benjamin L. Miller, Berislav V. Zloković   +15 more
openalex   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source