Results 221 to 230 of about 5,368,097 (298)

Orexin, Sleep, and Cognition in Alzheimer Disease: Non-REM Oscillatory Activity and Neural Resilience. [PDF]

Neurology
Paez A, Piñol-Ripoll G, Carnes-Vendrell A, Dakterzada F, Barbé F, Zetterberg H, Dang-Vu TT.   +6 more
europepmc   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

A Harmonized Visual Reading Framework for Tau PET Staging in Alzheimer Disease.

JAMA Neurol
Ruppert E, Vermeiren MR, Scop Medeiros M, Povala G, Soares C, Rocha A, de Oliveira Franco A, Scarpatto Rodrigues M, Oliveira M, Mroué R, Ferreira PCL, Bauer-Negrini G, Lussier FZ, Amaral L, Bellaver B, Tissot C, Masdeu J, Tudorascu DL, Karikari T, Soleimani-Meigooni DN, Fortea J, Lowe VJ, Oh H, Pascual B, Gordon BA, Rosa-Neto P, Baker S, Ossenkoppele R, van de Giessen E, Pascoal TA, HEAD study.   +30 more
europepmc   +1 more source

Brain organoids in Alzheimer disease and related tauopathies: Challenges and opportunities for translational readiness. [PDF]

Stem Cell Reports
Guruacharya A, Hartung T, Souza Dos Reis R, Moreira NCDS, Attisano L, Bolognin S, Iqbal K, Rajbanshi B.   +7 more
europepmc   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Clinical Meaningfulness of Donanemab in Early Symptomatic Alzheimer Disease: Data From the Randomized Phase 3 TRAILBLAZER-ALZ 2 Trial. [PDF]

Neurol Clin Pract
Atri A, Apostolova LG, Iwata A, Wessels AM, Atkins A, Lu M, Ye W, Ryan S, Doty EG.   +8 more
europepmc   +1 more source

Acoustically Activatable Drug‐Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors

Advanced Science, EarlyView.
Microfluidically fabricated drug‐loaded nanodroplets are sequentially activated by dual‐frequency ultrasound through acoustic droplet vaporization followed by bubble collapse, enabling spatially controlled drug release and mechanical tumor fractionation, resulting in synergistic mechanochemotherapy and prolonged survival.
Tiran Bercovici, Mike Bismuth, Meir Goldsmith, Dan Peer, Tali Ilovitsh   +4 more
wiley   +1 more source

Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries. [PDF]

Neurol Genet
Caro-Châtelier I, Sargurupremraj M, Yang C, Akinleye C, Trégouët DA, Akinyemi RO, Shigemizu D, Coker M, Akinyemi JO, Tiwari HK, Chasman DI, Ovbiagele B, Chabriat H, Mooser V, Couffinhal T, Mishra A, Cruchaga C, Reitz C, Kunkle B, Kamatani Y, Owolabi MO, Mohammedi K, Debette S.   +22 more
europepmc   +1 more source

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Clinical Impact and Prognostic Value of Alzheimer Disease Biomarkers in the Very Old. [PDF]

Neurology
Ceriello C, Torres OH, Rubio-Guerra S, García-Castro J, Selma-Gonzalez J, Sala I, Sánchez-Saudinós MB, Videla L, Vera-Campuzano E, Arranz J, Rodríguez-Baz Í, Maure-Blesa L, Dols-Icardo O, Valldeneu S, Barroeta I, Santos-Santos M, Carmona-Iragui M, Vaqué-Alcázar L, Alvarez-Sanchez E, Lorente O, Carreras M, Bejanin A, Belbin O, Lleó A, Fortea J, Alcolea D, Illán-Gala I.   +26 more
europepmc   +1 more source