Results 181 to 190 of about 362,575 (339)

Cognitive and Brain Reserve as Modifiers of Early Alzheimer Disease-Related Cognitive Vulnerability. [PDF]

Neurology
Sewell KR, Solis-Urra P, Huang H, Karikari TK, Grove G, Kramer AF, McAuley E, Burns JM, Hillman CH, Vidoni ED, Morris JK, Marsland AL, Kang C, Sutton BP, Wan L, Kamboh MI, Gianaros PJ, Drake JA, Stern Y, Oberlin LE, Erickson KI.   +20 more
europepmc   +1 more source

Quantitative 18F-AV1451 brain tau PET imaging in cognitively normal older adults, mild cognitive impairment, and Alzheimer\u27s disease patients [PDF]

, 2019
Alzheimer\u27s Disease Neuroimaging Initiative,, Ha, Lingxia, Liu, Min, Zhao, Qian, Zhou, Yun   +4 more
core   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Alzheimer Disease [PDF]

Mayo Clinic Proceedings, 2016
Mark E, Jentoft, Lori A, Erickson
openaire   +2 more sources

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Blood-Based Biomarkers for Alzheimer Disease: Preventing Unintended Consequences. [PDF]

JAMA
Whitson HE, Fowler NR, Mielke MM.
europepmc   +1 more source

Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain

Advanced Science, EarlyView.
A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio, Tommaso Gili, Andrea Gabrielli, Maurizio Mattia   +3 more
wiley   +1 more source

Epilepsy and Alzheimer Disease: Epidemiologic, Clinical, Molecular, and Neuropathologic Convergences and Divergences. [PDF]

Neurol Clin Pract
Devinsky O, Leitner DF, Kamondi A, Wisniewski T.   +3 more
europepmc   +1 more source

Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology [PDF]

, 2018
Ances, Beau M, Benzinger, Tammie L.S, Blazey, Tyler M, Christensen, John, Dincer, Aylin, Gordon, Brian A, Hornbeck, Russ C, Jackson, Kelley, McCullough, Austin, Mishra, Shruti, Morris, John C, Su, Yi   +11 more
core   +2 more sources

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source