Results 161 to 170 of about 5,368,097 (298)

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Prevalence of metabolic syndrome among patients with Alzheimer disease: A systematic review and meta-analysis. [PDF]

Medicine (Baltimore)
Amouzad-Lichahi M, Petkov I, Smerat A, Alsarhan HW, Letafatkar N, Abbasnejad-Ardehroudkenari M, Mohammadi S, Jafari M, Ghodous S, Amini-Salehi E.   +9 more
europepmc   +1 more source

Dementia caregiving in Nevada: Data from the 2016 Behavioral Risk Factor Surveillance System

In Nevada, more than half of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for ...

core  

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Lecanemab use for early Alzheimer disease in Canada. [PDF]

CMAJ
Weiss SM, Watt JA, Ewa V, Straus SE.
europepmc   +1 more source

Dementia Caregiving in Kentucky: Data from the 2015 Behavioral Risk Factor Surveillance System

In Kentucky, more than half of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for ...

core  

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

Spatiotemporal characterization of Alzheimer disease pathology in living human brain tissue. [PDF]

Nat Commun
Aslanyan A, Mukherjee S, Moncur EM, Szadziewska A, He Y, Kac PR, Coyle R, Camporesi E, Sato C, Ghoshal N, Barthélemy NR, Wood J, Ge J, Dulewicz M, Koutarapu S, Schwetye K, Roberts KF, Murphy EC, Carletti F, Blennow K, Gonzalez Ortiz F, Leckey CA, Giovannucci TA, Tariq K, Zetterberg H, Elbert DL, Thorne L, Toma AK, Watkins L, Fox NC, Bateman RJ, Hanrieder J, Paterson RW.   +32 more
europepmc   +1 more source

Dementia caregiving in New Jersey: Data from the 2016 Behavioral Risk Factor Surveillance System

In New Jersey, half of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for Disease ...

core  

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source