Results 161 to 170 of about 202,263 (297)

Why it should be "Alzheimer disease" rather than "Alzheimer's disease". [PDF]

Free Neuropathol
Aguero C, Klein CZ, Haase G.
europepmc   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Dementia Caregiving in Wisconsin: Data from the 2015 Behavioral Risk Factor Surveillance System

In Wisconsin, nearly half of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for ...

core  

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Dementia Caregiving in Louisiana: Data from the 2015 Behavioral Risk Factor Surveillance System

In Louisiana, more than 60 percent of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers ...

core  

Cognitive and Brain Reserve as Modifiers of Early Alzheimer Disease-Related Cognitive Vulnerability. [PDF]

Neurology
Sewell KR, Solis-Urra P, Huang H, Karikari TK, Grove G, Kramer AF, McAuley E, Burns JM, Hillman CH, Vidoni ED, Morris JK, Marsland AL, Kang C, Sutton BP, Wan L, Kamboh MI, Gianaros PJ, Drake JA, Stern Y, Oberlin LE, Erickson KI.   +20 more
europepmc   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

Dementia caregiving in North Dakota: Data from the 2016 Behavioral Risk Factor Surveillance System

In North Dakota, more than half of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for

core  

Blood-Based Biomarkers for Alzheimer Disease: Preventing Unintended Consequences. [PDF]

JAMA
Whitson HE, Fowler NR, Mielke MM.
europepmc   +1 more source

Orthogonal Ionic Liquid‐Based Extraction Strategy Enables Amyloid‐Specific Profiling of Aggregate Proteome

Advanced Science, EarlyView.
An orthogonal ionic‐liquid extraction (Orth‐iEA) enables selective isolation of amyloid fibrils. TMGBF4 disrupts hydrogen‐bonded β‐sheet networks to solubilize amyloid aggregates, whereas C12ImCl interacts with hydrophobic regions of non‐amyloid proteins.
Shiying Zheng, Ye Liu, Bowen Zhong, Huiying Chu, Zhou Gong, Baofeng Zhao, Mengchun Cheng, Zhen Liang, Yukui Zhang, Qun Zhao, Lihua Zhang   +10 more
wiley   +1 more source