Results 151 to 160 of about 4,881,215 (246)

Dementia caregiving in New Jersey: Data from the 2016 Behavioral Risk Factor Surveillance System

In New Jersey, half of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for Disease ...

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Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Dementia caregiving in Minnesota: Data from the 2016 Behavioral Risk Factor Surveillance System

In Minnesota, more than half of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for ...

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CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Dementia Caregiving in Maine: Data from the 2015 Behavioral Risk Factor Surveillance System

In Maine, more than half of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for ...

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Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Dementia Caregiving in Louisiana: Data from the 2015 Behavioral Risk Factor Surveillance System

In Louisiana, more than 60 percent of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers ...

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ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

Dementia Caregiving in Wisconsin: Data from the 2015 Behavioral Risk Factor Surveillance System

In Wisconsin, nearly half of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for ...

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CONCEPTS OF ALZHEIMER DISEASE: BIOLOGICAL, CLINICAL, AND CULTURAL PERSPECTIVES

, 2000
Preface -- Acknowledgments -- List of contributors -- Pt. I. The cases of Auguste D. and Johann F.: origins of the modern concept of Alzheimer disease -- Ch. 1.

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