Results 171 to 180 of about 5,368,097 (298)

Clinical Factors Associated With Discordant Plasma P-Tau217 and Established Alzheimer Disease Biomarkers. [PDF]

Neurology
Shir D, Algeciras-Schimnich A, Piura YD, Bornhorst JA, Figdore DJ, Elgenidi A, Lachner C, Graff-Radford NR, Day GS.   +8 more
europepmc   +1 more source

Dementia caregiving in Minnesota: Data from the 2016 Behavioral Risk Factor Surveillance System

In Minnesota, more than half of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for ...

core  

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Anti-Amyloid Monoclonal Antibodies in Early Alzheimer Disease: Lecanemab and Donanemab. [PDF]

Neurol Int
Demir ÜF, Karakuş Dilbaz F.
europepmc   +1 more source

Dementia caregiving in New York: Data from the 2016 Behavioral Risk Factor Surveillance System

In New York, more than 60 percent of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers ...

core  

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

Technology-natives and technology-adopters: Age differences in remote cognitive assessment in Alzheimer disease. [PDF]

Alzheimers Dement
Katteri S, Wilks H, Welhaf M, Aschenbrenner AJ, Frank CC, Vila-Castelar C, Stout S, Sliwinski MJ, Benzinger TL, Florencia Clarens M, Cruchaga C, Daniels A, Day GS, Devenney E, Gordon BA, Huey ED, Ikeuchi T, Ishiguro T, Ibanez L, Jucker M, Karch C, Levin J, Perrin R, Renton A, Supnet-Bell C, Weston PSJ, Xiong C, Libre-Guerra J, McDade EM, Bateman RJ, Morris JC, Dominantly Inherited Alzheimer Network, Hassenstab J.   +32 more
europepmc   +1 more source

Dementia Caregiving in Iowa: Data from the 2015 Behavioral Risk Factor Surveillance System

In Iowa, more than one-third of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for ...

core  

Polymer Concepts in Cellular Function

Advanced Science, EarlyView.
Miao Yu, Shikha Dhiman, Dorothee Dormann, Frauke Gräter, Katja Luck, Friederike Schmid, Andreas Walther, Edward A. Lemke   +7 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source