Results 241 to 250 of about 317,693 (354)

The Course of Psychopathologic Features in Mild to Moderate Alzheimer Disease

, 1997
Davangere P. Devanand
openalex   +2 more sources

Alzheimer's disease

, 2014
openaire   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose

, 1999
Suzanne Craft, Sanjay Asthana, John W. Newcomer, Charles W. Wilkinson, Ines Matos, Laura D. Baker, Monique Cherrier, Cassin Lofgreen, Shawn J. Latendresse, Andreana Petrova, Stephen R. Plymate, Murray A. Raskind, Keith Grimwood, Richard C. Veith   +13 more
openalex   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Medicaid Payments and Racial and Ethnic Disparities in Alzheimer Disease Special Care Units.

JAMA Netw Open
Xu H, Li S, Bowblis JR, Pappadis MR, Kuo YF, Goodwin JS.   +5 more
europepmc   +1 more source

Sildenafil and risk of Alzheimer disease: a systematic review and meta-analysis. [PDF]

Aging (Albany NY)
Chua WY, Lim LKE, Wang JJD, Mai AS, Chan LL, Tan EK.   +5 more
europepmc   +1 more source

Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology [PDF]

, 2018
Ances, Beau M, Benzinger, Tammie L.S, Blazey, Tyler M, Christensen, John, Dincer, Aylin, Gordon, Brian A, Hornbeck, Russ C, Jackson, Kelley, McCullough, Austin, Mishra, Shruti, Morris, John C, Su, Yi   +11 more
core   +2 more sources

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

Advanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie, Tianyi Ji, Zixin Wan, Jie Huang, Han Li, Lingjiao Zou, Zhen Yang, Jiarui Li, Yuqi Guan, Lei Ruan, Jinhua Yan, Cuntai Zhang   +11 more
wiley   +1 more source

Pilot Study: Lymphatic Brain Decongestion: A New Surgical Technique in Alzheimer Disease. [PDF]

Plast Reconstr Surg Glob Open
Topalis A, Bekiari C, Demiri E, Dionyssiou D.   +3 more
europepmc   +1 more source