Results 261 to 270 of about 9,708,599 (370)

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Diffusion‐MRI‐Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains

Advanced Science, EarlyView.
We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu, Minhui Ouyang, Shufang Tan, Jianlin Guo, Ziqin Zhang, Xuan Liu, Risheng Liu, Hao Huang   +7 more
wiley   +1 more source

Predictive Model of Acupuncture Adherence in Alzheimer Disease: Secondary Analysis of Randomized Controlled Trials. [PDF]

JMIR Aging
Chen ZH, Li R, Jiang YH, He JK, Yan SS, Zong GH, Yi ZX, Ren XY, Jia BH.   +8 more
europepmc   +1 more source

Alzheimer disease in the United States (2010–2050) estimated using the 2010 census

Neurology, 2013
L. Hebert, J. Weuve, P. Scherr, Denis A. Evans   +3 more
semanticscholar   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Assessment of outcome in clinical trials in mild Alzheimer�s disease: Urgent time for a rethink?

, 2013
Yvonne Morrison, Lindsay Wilson, Fiona Kelly, Cathy Bennett, Fergal J. Duffy, Sean J.F. McGoldrick, Emma Reynish   +6 more
openalex   +1 more source

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

Nature Genetics, 2019
I. Jansen, J. Savage, Kyoko Watanabe, J. Bryois, Dylan M. Williams, S. Steinberg, J. Sealock, I. Karlsson, S. Hägg, L. Athanasiu, N. Voyle, P. Proitsi, Aree Witoelar, Sven Stringer, D. Aarsland, I. S. Almdahl, Fred Andersen, S. Bergh, F. Bettella, Sigurbjorn Bjornsson, Anne Brækhus, G. Bråthen, C. D. de Leeuw, R. Desikan, S. Djurovic, L. Dumitrescu, T. Fladby, T. Hohman, P. Jonsson, S. Kiddle, A. Rongve, I. Saltvedt, S. Sando, G. Selbæk, M. Shoai, N. Skene, J. Snaedal, E. Stordal, I. Ulstein, Yunpeng Wang, L. White, J. Hardy, J. Hjerling-Leffler, P. Sullivan, W. M. van der Flier, R. Dobson, L. Davis, H. Stefánsson, K. Stefánsson, N. Pedersen, S. Ripke, O. Andreassen, D. Posthuma   +52 more
semanticscholar   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source