Results 261 to 270 of about 317,693 (354)

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Advanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu, Jia Chen, Fangzhou Wang, Dongdong Jia, Shuguang Bi, Yuming Mao, Yu‐qi Zhang, Tian‐long Gao, Liu Yang, Jia‐xu Du, Zi‐han Zhou, Xi‐Chen Zhu, Gao‐shang Chai   +12 more
wiley   +1 more source

Cerebrospinal Fluid Amyloid and Tau Biomarker Changes Across the Alzheimer Disease Clinical Spectrum.

JAMA Netw Open
de Leeuw DM, Trieu C, Vromen EM, Blujdea ER, Verberk IMW, Duits FH, Teunissen CE, Pijnenburg YAL, van der Flier WM, van Harten AC, Visser PJ, Tijms BM.   +11 more
europepmc   +1 more source

Linking Lymphedema, Chronic Inflammation, Oxidative Stress, Alzheimer Disease, and Potential Role of Lymphaticovenous Anastomosis. [PDF]

Plast Reconstr Surg Glob Open
Yang JC, Kuo PJ, Chang C, Wang YM, Ou YC, Cheng YC, Wu SC, Chien PC, Hsieh CH, Lin WC.   +9 more
europepmc   +1 more source

Version 3 of the Alzheimer Disease Centers’ neuropsychological test battery in the Uniform Data Set (UDS) [PDF]

, 2018
al., et, Morris, John C., Weintraub, Sandra   +2 more
core   +1 more source

No Genetic Effect of α1-Antichymotrypsin in Alzheimer Disease

, 1996
Jonathan L. Haines, M.L. Pritchard, Ann M. Saunders, J.M. Schildkraut, John H. Growdon, P. C. Gaskell, Lindsay A. Farrer, Sanford A. Auerbach, James F. Gusella, P. A. Locke, B.L. Rosi, Larry H. Yamaoka, Gary W. Small, P. M. Conneally, Allen D. Roses, M. A. Pericak‐Vance   +15 more
openalex   +1 more source

Red Blood Cell Membrane Lipidomics: Potential Biomarkers Detecting Method for Plasma Volume Overload and Major Adverse Cardiovascular Events in Chronic Heart Failure Patients

Advanced Science, EarlyView.
A novel RBC indicator, ESI, is better than the traditional RBC indicators and is associated with CHF prevalence and in‐hospital death. RBC membrane lipidomics, Cer 18:0;O2/16:0, and LPE 18:0, are associated with plasma volume overload and MACE in CHF patients, but these plasma lipids could not.
Lin Zhang, Xiangqin Ou, Jingyi Lin, Xiaofei Luo, Jiashun Zhou, Xingyue Zhou, Peihua Zhao, Li Liu, Ziran Zhao, Ying Zhou, Guanwei Fan, Lifeng Han, Xiumei Gao   +12 more
wiley   +1 more source

Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24.3) associated with familial Alzheimer disease (AD3 locus)

, 1996
Michael K. Trower, Sarah Orton, Ian J. Purvis, Philippe Sanséau, J. Riley, Chri Christodoulou, Doreen Burt, C.G. See, Greg Elgar, Robin Sherrington, Е. И. Рогаев, Peter St George‐Hyslop, Sydney Brenner, Colin W. Dykes   +13 more
openalex   +1 more source

Parvalbumin Interneuron‐Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker

Advanced Science, EarlyView.
This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan, Yunxuan Wang, Xufan Deng, Shiyu Wu, Yifan Pan, Jun Du, Mei Yu, Bo Liu, Huimei Wang, Zhengyu Zhang, Jinghong Chen, Shuifa Chen, Yizheng Wang, Tara Walker, Perry Bartlett, Jun Ju, Sheng‐Tao Hou   +16 more
wiley   +1 more source

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

Perspectives on ethnic and racial disparities in Alzheimer\u27s disease and related dementias: Update and areas of immediate need [PDF]

, 2019
Babulal, Ganesh M, et al,, Roe, Catherine M   +2 more
core   +1 more source