Results 281 to 290 of about 317,693 (354)

Research Participant Interest in Learning Results of Biomarker Tests for Alzheimer Disease.

JAMA Netw Open
Goswami S, Hartz SM, Oliver A, Jackson S, Ogungbenle T, Evans A, Linnenbringer E, Moulder KL, Morris JC, Mozersky J.   +9 more
europepmc   +1 more source

More Than <i>APOE</i>: Genetic Predictors in Alzheimer Disease in <i>APOE</i>ε3 Carriers. [PDF]

Neurol Genet
Peters N, Unschuld PG.
europepmc   +1 more source

Enhanced Brain‐Heart Connectivity as a Precursor of Reduced State Anxiety after Therapeutic Virtual Reality Immersion

Advanced Science, EarlyView.
This study shows that enhanced brain‐to‐heart coupling is a precursor of anxiety reduction following a virtual reality‐based non‐pharmacological intervention. Driven by midline beta rhythms, this effect suggests the involvement of central‐autonomic interactions.
Idil Sezer, Paul Moreau, Mohamad El Sayed Hussein Jomaa, Valérie Godefroy, Bénédicte Batrancourt, Richard Lévy, Anton Filipchuk   +6 more
wiley   +1 more source

Associations of Cerebrospinal Fluid Orexin-A, Alzheimer Disease Biomarkers, and Cognitive Performance. [PDF]

Ann Clin Transl Neurol
Lu R, Shah K, Toedebusch CD, Hess A, Richardson R, Mignot E, Schindler SE, Benzinger TLS, Flores S, Hassenstab J, Xiong C, Morris JC, Holtzman DM, Lucey BP.   +13 more
europepmc   +1 more source

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Advanced Science, EarlyView.
Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria   +10 more
wiley   +1 more source

Challenges in a Biological Definition of Alzheimer Disease. [PDF]

Neurology
europepmc   +1 more source

Comorbidities in early-onset sporadic versus presenilin-1 mutation-associated Alzheimer disease dementia: Evidence for dependency on Alzheimer disease neuropathological changes. [PDF]

J Neuropathol Exp Neurol
Sepulveda-Falla D, Villegas Lanau CA, White Iii C, Serrano GE, Acosta-Uribe J, Mejía-Cupajita B, Villalba-Moreno ND, Lu P, Glatzel M, Kofler JK, Ghetti B, Frosch MP, Restrepo FL, Kosik KS, Beach TG.   +14 more
europepmc   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, EarlyView.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source

Patient-Related Barriers to Digital Technology Adoption in Alzheimer Disease: Systematic Review. [PDF]

JMIR Aging
Panzavolta A, Arighi A, Guido E, Lavorgna L, Di Lorenzo F, Dodich A, Cerami C.   +6 more
europepmc   +1 more source

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

Advanced Science, EarlyView.
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu, Zhongding Li, Kate Lykke Lambertsen, Zijun Cao, Meng Chen, Yanqi Xu, Bettina Hjelm Clausen, Keshuo Jin, Yiting Lu, Fuqi Mei, Xue Du, Kangmin Chen, Huiyuan Bai, Xian Su, Bincheng Zhou, Baohua Liu, Ran Li, Chaoqun Wang, Yuhua Li, Xiang Cai, Dirk Schlüter, Weihong Song, Xu Wang   +22 more
wiley   +1 more source