Results 51 to 60 of about 317,693 (354)

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Identification and description of three families with familial Alzheimer disease that segregate variants in the SORL1 gene

Acta Neuropathologica Communications, 2017
Alzheimer disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. The majority of AD cases are sporadic, while up to 5% are families with an early onset AD (EOAD).
Håkan Thonberg, Huei-Hsin Chiang, Lena Lilius, Charlotte Forsell, Anna-Karin Lindström, Charlotte Johansson, Jenny Björkström, Steinunn Thordardottir, Kristel Sleegers, Christine Van Broeckhoven, Annica Rönnbäck, Caroline Graff   +11 more
doaj   +1 more source

The conceptual relevance of assessment measures in patients with mild/mild-moderate Alzheimer\u27s disease [PDF]

, 2018
Introduction: This study aims to evaluate the conceptual relevance of four measures of disease activity in patients with mild/mild-moderate Alzheimer\u27s disease (AD): (1) the Alzheimer\u27s Disease Assessment Scale–Cognitive Subscale; (2) the Alzheimer\
Al-Zubeidi, Tamara, Aldhouse, Natalie V.J., Hartry, Ann, Knight, Sarah L., Sanon, Myrlene, Stefanacci, Richard G.   +5 more
core   +1 more source

[Anesthesia and Alzheimer disease - Current perceptions] [PDF]

, 2018
BACKGROUND AND OBJECTIVES: It has been speculated that the use of anesthetic agents may be a risk factor for the development of Alzheimer disease.
Lapa, TA, Marques, AF
core   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

EMBO Molecular Medicine, 2020
Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathways is unknown.
Annerieke Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesus Zoco, David Blum, Luc Buée, Bart De Strooper, Mark Fiers   +10 more
doaj   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Alzheimer\u27s Disease and Down\u27s Syndrome: An Overview [PDF]

, 2011
The association between Alzheimer\u27s Disease and Down\u27s Syndrome is well recognized through clinical observations and genetic studies. However, the exact nature and the implications of this link is far from clear as yet.
Desai, M.B.B.S., Dr.Devanshu
core   +1 more source

Evaluation of gene-based family-based methods to detect novel genes associated with familial late onset Alzheimer disease [PDF]

, 2018
Gene-based tests to study the combined effect of rare variants towards a particular phenotype have been widely developed for case-control studies, but their evolution and adaptation for family-based studies, especially for complex incomplete families ...
Budde, John, Cruchaga, Carlos, Del-Aguila, Jorge L, Deming, Yuetiva, Fernandez, Maria V, Goate, Alison M, Harari, Oscar, Ibanez, Laura, Morris, John C, NCRAD,, NIA-LOAD family study group,, Norton, Joanne   +11 more
core   +2 more sources

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source